- Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation
Analysis of a leaf extract used in African folk medicine reveals a high-affinity K+ channel agonist and its binding site.
- Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion
An inverted position after intrathecal AAV9 infusion markedly enhances gene delivery to the brain.
- Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme
Specific substrate recruitment by the protein phosphatase-1 molecule G subunit holoenzyme enables the maintenance of glucose levels.
- Impact of modular organization on dynamical richness in cortical networks
Balance of functional integrability and spatial segregation mediates dynamical richness in modular cortical networks.
- Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma
After decades of nonspecific lymphoma therapy, personalized approaches such as described here are on the horizon.
- Soil erosion is unlikely to drive a future carbon sink in Europe
Will the rain wash away our soil organic carbon under future climate change?
- Time-space–displaced responses in the orangutan vocal system
Wild orangutan mothers weigh the danger posed by predators and wait until it is safe to inform their dependent infants.
- Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli
Thanatin targets protein-protein interactions between LptA and LptD in the periplasmic bridge required for LPS transport.
- Long-term magmatic evolution reveals the beginning of a new caldera cycle at Campi Flegrei
The Campi Flegrei magma reservoir is entering a new built-up phase that may culminate in the future in a caldera-forming eruption.
- Natural climate solutions for the United States
U.S. land management can contribute 1.2 Pg CO2e year−1 of greenhouse gas mitigation, 76% of which costs USD 50 Mg CO2e−1 or less.
- Jasmonate promotes artemisinin biosynthesis by activating the TCP14-ORA complex in Artemisia annua
JA-induced JAZ8 degradation releases and activates the TCP14-ORA complex in enhancing artemisinin biosynthesis in Artemisia annua.
- A large impact crater beneath Hiawatha Glacier in northwest Greenland
Researchers present the first unambiguous discovery of a 31-km-wide impact crater buried beneath the Greenland Ice Sheet.
- Flexible elastomer patch with vertical silicon nanoneedles for intracellular and intratissue nanoinjection of biomolecules
A thin transparent wearable patch with silicon nanoneedles is developed for efficient interface with biological cells and tissues.
- Evidence for a quantum spin Hall phase in graphene decorated with Bi2Te3 nanoparticles
Topological insulating graphene is created using decoration of an extremely small quantity of heavy nanoparticles.
About The Cover
COVER Whether summer extreme weather events—floods, wildfires, droughts and heat waves—will increase in future years depends on competition between the warming effect of increasing greenhouse gases and the opposing effect of regional cooling from atmospheric pollutants called aerosols (which reflect sunlight back to space), a new study finds. Presently, assumptions about the nature and concentrations of aerosols in climate models differ, largely due to complex underlying chemistry and physics. This leads to different estimations of future summer weather events. Seeking a better grasp on the likelihood of an increase in extreme weather events in years ahead, Mann et al. modeled how summer events look in future as conditions favorable to quasi-resonant amplification (QRA)—a phenomenon whereby jetstream patterns showcase large undulations that lock in place, trapping weather systems between them—increase. In some simulations, these events actually decrease, largely because of aerosol's cooling effect, which offsets the warming from greenhouse gases. Ultimately, say the authors, how summer event intensity and frequency will play out in future is critically dependent on human behaviors related to fossils fuels and aerosols. [CREDIT: MARK THIESSEN/NATIONAL GEOGRAPHIC IMAGE COLLECTION]