- Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
A rational approach enables the almost complete suppression of nucleation events in Aβ42 aggregation using designed antibodies.
- Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters
Mammalian condensin II associates with specific sites via interactions with TFIIIC and H3K4me3 and supports gene expression.
- WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death
WNT antagonism displays marked synergy with taxane chemotherapy and reverses taxane-induced enrichment of cancer stem cells.
- Instant tough bonding of hydrogels for soft machines and electronics
A strategy for bonding water-rich hydrogels to diverse materials for electronic skins, energy storage, and soft optics is reported.
- Two orders of magnitude enhancement in oxygen evolution reactivity on amorphous Ba0.5Sr0.5Co0.8Fe0.2O3−δ nanofilms with tunable oxidation state
A novel strategy to tweak the oxygen evolution activity of nanofilms by exploiting the film-substrate redox interaction.
- A general strategy to synthesize chemically and topologically anisotropic Janus particles
A general emulsion interfacial polymerization strategy opens a new avenue for the large-scale synthesis of “god” Janus particles.
- Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation
Activating T cells reorganize their cortical actin to form a ramified transportation network beneath the immunological synapse.
- Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice
Serotonin enhancement during developmental stages restores autism symptoms in a mouse model of human 15q11-13 duplication.
- Cost-effective conservation of amphibian ecology and evolution
A new conservation strategy incorporates functional, phylogenetic, and taxonomic diversity for improved cost-effective outcomes.
- Sub–100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA
Programmable DNA-based metafluorophores allow simultaneous tagging and imaging with more than 100 virtual colors.
- Ligand binding to a G protein–coupled receptor captured in a mass spectrometer
Drug binding to the P2Y1 receptor prevents phosphorylation and competes with an endogenous ligand.
- Morphology controls the thermoelectric power factor of a doped semiconducting polymer
The orientational correlation length of domains in a semiconducting polymer controls its thermoelectric performance.
- Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer
Hyperpolarized micro-NMR nondestructively analyzes metabolic activities in scant cells.
- Splitting of the O–O bond at the heme-copper catalytic site of respiratory oxidases
We present a mechanism by which oxygen is reduced to water in living organisms.