- Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory
Inhibiting DNA replication in C. elegans embryos causes loss of repressive histone modifications and generates epialleles.
- Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5
ERK5 regulates nonlytic expulsion of live pathogens from phagocytes to limit dissemination of infections.
- From the surface to the seafloor: How giant larvaceans transport microplastics into the deep sea
Larvaceans can filter microplastics from the water and package them into their fecal pellets, transporting them into the deep sea.
- Adult-onset obesity is triggered by impaired mitochondrial gene expression
Reduction in an RNA binding protein impairs mitochondrial biogenesis and alters cell signaling, resulting in obesity.
- Carryover effects of larval exposure to different environmental bacteria drive adult trait variation in a mosquito vector
The adult phenotype of mosquitoes depends on the types of bacteria encountered environmentally during development.
- The evolutionary basis of premature migration in Pacific salmon highlights the utility of genomics for informing conservation
Accounting for specific alleles can be necessary to prevent the loss of significant biodiversity and ecosystem services.
- Seismic evidence for complex sedimentary control of Greenland Ice Sheet flow
Seismic data show that subglacial sediment slip causes a complex flow response of the Greenland Ice Sheet to climate warming.
- The role of floridoside in osmoadaptation of coral-associated algal endosymbionts to high-salinity conditions
In response to high salinity, algal endosymbionts of corals produce floridoside, an osmolyte with antioxidant potential.
- Large polarons in lead halide perovskites
Charge carriers in both hybrid and all-inorganic lead halide perovskites form large polarons.
- A molecular quantum spin network controlled by a single qubit
Control of molecular spins and their readout with a solid-state qubit are described as a unit cell in a quantum spin network.
- 3D imaging of optically cleared tissue using a simplified CLARITY method and on-chip microscopy
Using lens-free holographic microscopy, we demonstrated 3D imaging in optically cleared tissue over a thickness of 0.2 mm.
- HfSe2 and ZrSe2: Two-dimensional semiconductors with native high-κ oxides
Atomically thin two-dimensional semiconductors feature silicon-like band gaps and native high-κ metal oxides.
- Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling
Acetylated scaffold protein CNK1 promotes ERK-dependent cell proliferation and migration in normal cells and in tumor cells.
- From the generalized reflection law to the realization of perfect anomalous reflectors
Nonlocal metasurface for perfect anomalous reflection demonstrates a new possibility for controlling electromagnetic energy flow.
About The Cover
August Online Cover of Science Advances shows a laborer working at a brickyard kiln in Noida, India, suffering the effects of a blistering heat wave that hovered above 45 degree Celsius (113F). This issue features a research article detailing advances in accurately calculating and understanding local and regional impacts of climate change. The research presents models that project risks from new types of extreme heat waves that are likely to hit regional hotspots , particularly across South Asia, towards the end of the 21st century. The authors identify areas where climate change, in absence of significant mitigation, is likely to severely impact human health and habitability in one of the most heavily populated regions on Earth. [Photo credit: Burhaan Kinu/Hindustan Times via Getty Images]