- pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM
Comparison of closed and open channels defines pH-dependent gating mechanism and cooperativity between protomers in the hexamer.
- Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model.
The causative progeria lamin A mutation inhibits CK2 enzyme activity to accelerate aging in laboratory mice.
- Dual complementary liposomes inhibit triple-negative breast tumor progression and metastasis
Dual complementary liposomes inhibit proliferation and metastasis in triple-negative breast cancer.
- Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans
Administering the anesthetic propofol after a brief reminder reduces retrieval of established emotional memory 24 hours later.
- Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence
The stringent response enzyme is a promising new target for Mycobacterium tuberculosis persisters.
- How cardiolipin modulates the dynamics of respiratory complex I
Cardiolipin induces conformational changes in complex I that modulate the accessibility of the quinone substrate to the enzyme.
- Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels
We engineered a photocrosslinkable and transparent bioadhesive hydrogel for quick sealing, and repair of corneal defects.
- Predatory fish invasion induces within and across ecosystem effects in Yellowstone National Park
Invasion of Yellowstone Lake by lake trout displaced bears and other cutthroat trout consumers in Yellowstone National Park.
- Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex
Neutrons reveal previously unknown protonation states of amino acid residues in protein kinase A—a prototype for the kinase family.
- Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
KDS2010, a MAO-B inhibitor, shows a long-lasting effect in alleviating memory impairment in an Alzheimer’s disease mouse model.
- A previously unrecognized source of the O2 Atmospheric band emission in Earth’s nightglow
Energy transfer from vibrationally excited OH to O atoms leads to enhanced O2 nightglow in Earth’s upper atmosphere.
- Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis
A broadened perspective on neovascularization is achieved by mimicking the vascular regenerative microenvironment in vitro.
- A hidden state in the turnover of a functioning membrane protein complex
We discovered a hidden state in the turnover of the torque-generating units of the bacterial flagellar rotary motor.
- Codweb: Whole-genome sequencing uncovers extensive reticulations fueling adaptation among Atlantic, Arctic, and Pacific gadids
Genome sequencing of codfish supporting large fisheries shows rampant hybridization providing fuel for their adaptations.
About The Cover
ONLINE COVER Real-time processing and manipulation of biological signals requires bioelectronic devices with integrated components capable of signal amplification, processing, and stimulation; Transistors form the backbone of such circuits. As represented on the March cover, Spyropoulos et al. have introduced an internal-ion gated organic electrochemical transistor (IGT) that uses contained mobile ions within the conducting polymer channel to permit both volumetric capacitance and shortened ionic transit time. The IGT has high transconductance, high speed, and can be independently gated to create scalable conformable integrated circuits. The authors demonstrate the ability of the IGT to provide a miniaturized, comfortable interface with human skin, using local amplification to record high quality brain neurophysiological activity. The IGT is an effective transistor architecture for enabling integrated, real-time sensing and stimulation of signals from living organisms. The cover image highlights the conformability and biocompatibility of this transistor architecture and materials by demonstrating IGT-based digital logic gates conforming to the surface of orchid petals. Scale bar, 10 mm. [CREDIT: GEORGE SPYROPOULOS, PHD/COLUMBIA UNIVERSITY]