Research ArticleALZHEIMER’S DISEASE
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
- James Keaney1,
- Dominic M. Walsh2,
- Tiernan O’Malley2,
- Natalie Hudson1,
- Darragh E. Crosbie1,
- Teresa Loftus3,
- Florike Sheehan3,
- Jacqueline McDaid1,
- Marian M. Humphries1,
- John J. Callanan4,5,
- Francesca M. Brett3,
- Michael A. Farrell3,
- Peter Humphries1 and
- Matthew Campbell1,*
- 1Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
- 2Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
- 3Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
- 4UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.
- 5Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies.
- ↵*Corresponding author. E-mail: matthew.campbell{at}tcd.ie
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Science Advances 18 Sep 2015:
Vol. 1, no. 8, e1500472
DOI: 10.1126/sciadv.1500472
Vol. 1, no. 8, e1500472
DOI: 10.1126/sciadv.1500472
James Keaney
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Dominic M. Walsh
Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Tiernan O’Malley
Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Natalie Hudson
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Darragh E. Crosbie
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Teresa Loftus
Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Florike Sheehan
Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Jacqueline McDaid
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Marian M. Humphries
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
John J. Callanan
UCD School of Veterinary Medicine and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies.
Francesca M. Brett
Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Michael A. Farrell
Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland.
Peter Humphries
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Matthew Campbell
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
