Research ArticleNEUROSCIENCE

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease

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Science Advances  12 Feb 2016:
Vol. 2, no. 2, e1501244
DOI: 10.1126/sciadv.1501244

Article Information

vol. 2 no. 2

Online ISSN: 
History: 
  • Received for publication September 9, 2015
  • Accepted for publication December 2, 2015

Author Information

  1. Johnny Habchi1,
  2. Paolo Arosio1,
  3. Michele Perni1,
  4. Ana Rita Costa1,
  5. Maho Yagi-Utsumi1,
  6. Priyanka Joshi1,
  7. Sean Chia1,
  8. Samuel I. A. Cohen1,
  9. Martin B. D. Müller2,
  10. Sara Linse3,
  11. Ellen A. A. Nollen2,
  12. Christopher M. Dobson1,*,
  13. Tuomas P. J. Knowles1,* and
  14. Michele Vendruscolo1,*
  1. 1Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK.
  2. 2University of Groningen, University Medical Centre Groningen, European Research Institute for the Biology of Aging, 9700 AD Groningen, Netherlands.
  3. 3Department of Biochemistry and Structural Biology, Center for Molecular Protein Science, Lund University, PO Box 124, 221 00 Lund, Sweden.
  1. *Corresponding author. E-mail: mv245{at}cam.ac.uk (M.V.); tpjk2{at}cam.ac.uk (T.P.J.K.); cmd44{at}cam.ac.uk (C.M.D.)

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