Research ArticleCELL BIOLOGY
Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance
- Sachiko Nishimoto1,*,
- Daiju Fukuda2,*,†,
- Yasutomi Higashikuni3,
- Kimie Tanaka4,
- Yoichiro Hirata5,
- Chie Murata6,
- Joo-ri Kim-Kaneyama7,
- Fukiko Sato1,
- Masahiro Bando1,
- Shusuke Yagi2,
- Takeshi Soeki2,
- Tetsuya Hayashi8,
- Issei Imoto6,
- Hiroshi Sakaue1,
- Michio Shimabukuro9,10 and
- Masataka Sata2,†
- 1Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
- 2Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
- 3Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
- 4Division for Health Service Promotion, The University of Tokyo, Tokyo 113-8655, Japan.
- 5Department of Pediatrics, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
- 6Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
- 7Department of Biochemistry, Showa University School of Medicine, Tokyo 142-8555, Japan.
- 8Laboratory of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka 569-1094, Japan.
- 9Department of Cardio-Diabetes Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
- 10Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital, Okinawa 901-0243, Japan.
- ↵†Corresponding author. E-mail: daiju.fukuda{at}tokushima-u.ac.jp (D.F.); masataka.sata{at}tokushima-u.ac.jp (M.S.)
↵* These authors contributed equally to this work.
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Science Advances 25 Mar 2016:
Vol. 2, no. 3, e1501332
DOI: 10.1126/sciadv.1501332
Vol. 2, no. 3, e1501332
DOI: 10.1126/sciadv.1501332
Sachiko Nishimoto
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Daiju Fukuda
Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Yasutomi Higashikuni
Department of Cardiovascular Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Kimie Tanaka
Division for Health Service Promotion, The University of Tokyo, Tokyo 113-8655, Japan.
Yoichiro Hirata
Department of Pediatrics, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Chie Murata
Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Joo-ri Kim-Kaneyama
Department of Biochemistry, Showa University School of Medicine, Tokyo 142-8555, Japan.
Fukiko Sato
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Masahiro Bando
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Shusuke Yagi
Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Takeshi Soeki
Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Tetsuya Hayashi
Laboratory of Cardiovascular Pharmacotherapy and Toxicology, Osaka University of Pharmaceutical Sciences, Osaka 569-1094, Japan.
Issei Imoto
Department of Human Genetics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Hiroshi Sakaue
Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
Michio Shimabukuro
Department of Cardio-Diabetes Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital, Okinawa 901-0243, Japan.
Masataka Sata
Department of Cardiovascular Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan.
