Research ArticleMOLECULAR GENETICS

Saturation of recognition elements blocks evolution of new tRNA identities

Science Advances  29 Apr 2016:
Vol. 2, no. 4, e1501860
DOI: 10.1126/sciadv.1501860

You are currently viewing the abstract.

View Full Text

Abstract

Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific recognition signals that allowed them to be matured, modified, aminoacylated, and processed by the ribosome without compromising the fidelity or efficiency of protein synthesis. We show that saturation of recognition signals blocks the emergence of new tRNA identities and that the rate of nucleotide substitutions in tRNAs is higher in species with fewer tRNA genes. We propose that the growth of the genetic code stalled because a limit was reached in the number of identity elements that can be effectively used in the tRNA structure.

Keywords
  • tRNA identities
  • genetic code
  • evolution
  • ADAT
  • tRNA Gly

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

View Full Text

More Like This