Research ArticleSUPRAMOLECULAR CHEMISTRY

Mechanized azobenzene-functionalized zirconium metal-organic framework for on-command cargo release

Science Advances  03 Aug 2016:
Vol. 2, no. 8, e1600480
DOI: 10.1126/sciadv.1600480

You are currently viewing the abstract.

View Full Text

Abstract

Stimuli-responsive metal-organic frameworks (MOFs) have gained increasing attention recently for their potential applications in many areas. We report the design and synthesis of a water-stable zirconium MOF (Zr-MOF) that bears photoresponsive azobenzene groups. This particular MOF can be used as a reservoir for storage of cargo in water, and the cargo-loaded MOF can be further capped to construct a mechanized MOF through the binding of β-cyclodextrin with the azobenzene stalks on the MOF surface. The resulting mechanized MOF has shown on-command cargo release triggered by ultraviolet irradiation or addition of competitive agents without premature release. This study represents a simple approach to the construction of stimuli-responsive mechanized MOFs, and considering mechanized UiO-68-azo made from biocompatible components, this smart system may provide a unique MOF platform for on-command drug delivery in the future.

Keywords
  • Metal-organic framework
  • azobenzene
  • on-command release
  • zirconium
  • supramolecular complex

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

View Full Text

More Like This