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Somatic cell reprogramming-free generation of genetically modified pigs

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Science Advances  14 Sep 2016:
Vol. 2, no. 9, e1600803
DOI: 10.1126/sciadv.1600803

Article Information

vol. 2 no. 9

Online ISSN: 
History: 
  • Received for publication April 15, 2016
  • Accepted for publication August 17, 2016

Author Information

  1. Fuminori Tanihara1,2,*,
  2. Tatsuya Takemoto3,*,,
  3. Eri Kitagawa4,
  4. Shengbin Rao4,
  5. Lanh Thi Kim Do1,
  6. Akira Onishi5,6,
  7. Yukiko Yamashita3,
  8. Chisato Kosugi3,
  9. Hitomi Suzuki3,
  10. Shoichiro Sembon6,
  11. Shunichi Suzuki6,
  12. Michiko Nakai6,
  13. Masakazu Hashimoto7,
  14. Akihiro Yasue8,
  15. Munehide Matsuhisa2,
  16. Sumihare Noji9,
  17. Tatsuya Fujimura4,
  18. Dai-ichiro Fuchimoto6 and
  19. Takeshige Otoi1,
  1. 1Laboratory of Animal Reproduction, Faculty of Bioscience and Bioindustry, Tokushima University, 2272-1 Ishii, Myozai-gun, Tokushima 779-3233, Japan.
  2. 2Diabetes Therapeutics and Research Center, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
  3. 3Division of Embryology, Fujii Memorial Institute of Medical Sciences, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
  4. 4Research and Development Center, NH Foods Ltd., 3-3 Midorigahara, Tsukuba, Ibaraki 300-2646, Japan.
  5. 5Laboratory of Animal Reproduction, Department of Animal Science and Resources, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.
  6. 6Transgenic Pig Research Unit, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki, 305-0901, Japan.
  7. 7Laboratory for Embryogenesis, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
  8. 8Department of Orthodontics and Dentofacial Orthopedics, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8504, Japan.
  9. 9Department of Life System, Institute of Technology and Science, Tokushima University, 2-1 Minami-Jyosanjima-cho, Tokushima 770-8506, Japan.
  1. Corresponding author. Email: takemoto.tatsuya{at}tokushima-u.ac.jp (T.T.); otoi{at}tokushima-u.ac.jp (T.O.)
    • * These authors contributed equally to this work.

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