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Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features

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Science Advances  09 Sep 2016:
Vol. 2, no. 9, e1601017
DOI: 10.1126/sciadv.1601017

Article Information

vol. 2 no. 9

Online ISSN: 
History: 
  • Received for publication May 6, 2016
  • Accepted for publication August 11, 2016

Author Information

  1. Valentina Speranzini1,*,
  2. Dante Rotili2,
  3. Giuseppe Ciossani1,
  4. Simona Pilotto1,
  5. Biagina Marrocco1,
  6. Mariantonietta Forgione2,3,
  7. Alessia Lucidi2,
  8. Federico Forneris1,
  9. Parinaz Mehdipour4,
  10. Sameer Velankar5,
  11. Antonello Mai2,6, and
  12. Andrea Mattevi1,
  1. 1Department of Biology and Biotechnology, University of Pavia, 27100 Pavia, Italy.
  2. 2Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
  3. 3Center for Life Nano Science@Sapienza, Italian Institute of Technology, Viale Regina Elena 291, 00161 Rome, Italy.
  4. 4Department of Experimental Oncology, European Institute of Oncology, via Adamello 16, 20139 Milan, Italy.
  5. 5European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, Cambridgeshire CB10 1SD, U.K.
  6. 6Pasteur Institute–Cenci Bolognetti Foundation, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy.
  1. Corresponding author. Email: andrea.mattevi{at}unipv.it (A. Mattevi); antonello.mai{at}uniroma1.it (A. Mai)
  • * Present address: European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS90181, 38042 Grenoble Cedex 9, France.

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