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Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5

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Science Advances  01 Nov 2017:
Vol. 3, no. 11, e1701682
DOI: 10.1126/sciadv.1701682

Article Information

vol. 3 no. 11

Online ISSN: 
  • Received for publication May 19, 2017
  • Accepted for publication October 10, 2017

Author Information

  1. Edmund A. Griffin Jr.1,2,
  2. Philippe A. Melas3,4,
  3. Royce Zhou1,*,
  4. Yang Li1,
  5. Peter Mercado1,
  6. Kimberly A. Kempadoo3,
  7. Stacy Stephenson1,
  8. Luca Colnaghi3,,
  9. Kathleen Taylor1,
  10. Mei-Chen Hu1,
  11. Eric R. Kandel1,2,3,5,6, and
  12. Denise B. Kandel1,2,7
  1. 1Department of Psychiatry, Columbia University, 1051 Riverside Drive, New York, NY 10032 USA.
  2. 2New York State Psychiatric Institute, New York, NY 10032, USA.
  3. 3Department of Neuroscience, Columbia University, New York, NY 10032, USA.
  4. 4Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska University Hospital, Karolinska Institutet, 17176 Stockholm, Sweden.
  5. 5Kavli Institute for Brain Science, Columbia University, New York, NY 10032, USA.
  6. 6Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  7. 7Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
  1. Corresponding author. Email: erk5{at}
  • * Present address: Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

  • Present address: Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa, 19, 20156 Milan, Italy.


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Nov 20171753732802593
Dec 20171779502396
Jan 20184529984