Research ArticleHEALTH AND MEDICINE

Intracerebroventricular delivery of hematopoietic progenitors results in rapid and robust engraftment of microglia-like cells

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Science Advances  06 Dec 2017:
Vol. 3, no. 12, e1701211
DOI: 10.1126/sciadv.1701211

Article Information

vol. 3 no. 12

Online ISSN: 
History: 
  • Received for publication April 16, 2017
  • Accepted for publication November 8, 2017

Author Information

  1. Alessia Capotondo1,*,
  2. Rita Milazzo1,*,
  3. Jose M. Garcia-Manteiga2,
  4. Eleonora Cavalca1,3,
  5. Annita Montepeloso1,3,
  6. Brian S. Garrison4,5,
  7. Marco Peviani1,3,
  8. Derrick J. Rossi4,5 and
  9. Alessandra Biffi1,3,6,
  1. 1San Raffaele Telethon Institute for Gene Therapy, Division of Regenerative Medicine, Stem Cell and Gene Therapy, San Raffaele Scientific Institute, Milano, Italy.
  2. 2Centre for Translational Genomics and Bioinformatics, IRCCS San Raffaele Scientific Institute, Milano, Italy.
  3. 3Gene Therapy Program, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA 02115, USA.
  4. 4Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
  5. 5Program in Cellular and Molecular Medicine, Department of Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.
  6. 6Gene Therapy Program, Department of Medicine, Boston Children’s Hospital, Boston, MA 02115, USA.
  1. Corresponding author. Email: alessandra.biffi{at}childrens.harvard.edu
    • * These authors contributed equally to this work.

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