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In vivo genome editing improves motor function and extends survival in a mouse model of ALS

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Science Advances  20 Dec 2017:
Vol. 3, no. 12, eaar3952
DOI: 10.1126/sciadv.aar3952

Article Information

vol. 3 no. 12

Online ISSN: 
History: 
  • Received for publication November 2, 2017
  • Accepted for publication November 28, 2017

Author Information

  1. Thomas Gaj1,*,
  2. David S. Ojala2,
  3. Freja K. Ekman3,
  4. Leah C. Byrne4,,
  5. Prajit Limsirichai5 and
  6. David V. Schaffer1,2,4,
  1. 1Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
  2. 2Department of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.
  3. 3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  4. 4Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
  5. 5Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  1. Corresponding author. Email: schaffer{at}berkeley.edu
  • * Present address: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

  • Present address: Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213, USA.

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