Research ArticleBIOCHEMISTRY
Age-associated molecular changes are deleterious and may modulate life span through diet
- Sang-Goo Lee1,2,
- Alaattin Kaya1,
- Andrei S. Avanesov1,
- Dmitriy I. Podolskiy1,
- Eun Ju Song3,4,
- Du-Min Go5,
- Gwi-Deuk Jin6,
- Jae Yeon Hwang6,
- Eun Bae Kim6,7,
- Dae-Yong Kim5 and
- Vadim N. Gladyshev1,*
- 1Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 2Department of Bioinspired Science, Ewha Womans University, Seoul 03760, South Korea.
- 3Ewha Laboratory Animal Genomic Center, Institute of Molecular Life Sciences and Technology, Office of Research Affairs, Ewha Womans University, Seoul 03760, South Korea.
- 4Department of Veterinary Physiology, College of Veterinary Medicine, BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul 08826, South Korea.
- 5Laboratory of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea.
- 6Department of Animal Life Science, Kangwon National University, Chuncheon 24341, South Korea.
- 7Division of Applied Animal Science, Kangwon National University, Chuncheon 24341, South Korea.
- ↵*Corresponding author. Email: vgladyshev{at}rics.bwh.harvard.edu
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Science Advances 17 Feb 2017:
Vol. 3, no. 2, e1601833
DOI: 10.1126/sciadv.1601833
Vol. 3, no. 2, e1601833
DOI: 10.1126/sciadv.1601833
Sang-Goo Lee
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.Department of Bioinspired Science, Ewha Womans University, Seoul 03760, South Korea.
Alaattin Kaya
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Andrei S. Avanesov
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Dmitriy I. Podolskiy
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Eun Ju Song
Ewha Laboratory Animal Genomic Center, Institute of Molecular Life Sciences and Technology, Office of Research Affairs, Ewha Womans University, Seoul 03760, South Korea.Department of Veterinary Physiology, College of Veterinary Medicine, BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul 08826, South Korea.
Du-Min Go
Laboratory of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea.
Gwi-Deuk Jin
Department of Animal Life Science, Kangwon National University, Chuncheon 24341, South Korea.
Jae Yeon Hwang
Department of Animal Life Science, Kangwon National University, Chuncheon 24341, South Korea.
Eun Bae Kim
Department of Animal Life Science, Kangwon National University, Chuncheon 24341, South Korea.Division of Applied Animal Science, Kangwon National University, Chuncheon 24341, South Korea.
Dae-Yong Kim
Laboratory of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, South Korea.
Vadim N. Gladyshev
Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
