Research ArticleBIOMOLECULES

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

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Science Advances  10 Feb 2017:
Vol. 3, no. 2, e1601944
DOI: 10.1126/sciadv.1601944

Article Information

vol. 3 no. 2

Online ISSN: 
History: 
  • Received for publication August 16, 2016
  • Accepted for publication January 25, 2017

Author Information

  1. Vasilios Kalas1,2,3,
  2. Jerome S. Pinkner1,2,
  3. Thomas J. Hannan1,2,4,
  4. Michael E. Hibbing1,2,
  5. Karen W. Dodson1,2,
  6. Alex S. Holehouse3,5,
  7. Hao Zhang6,
  8. Niraj H. Tolia2,
  9. Michael L. Gross6,
  10. Rohit V. Pappu3,5,
  11. James Janetka6 and
  12. Scott J. Hultgren1,2,*
  1. 1Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  2. 2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  3. 3Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
  4. 4Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  5. 5Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
  6. 6Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
  1. *Corresponding author. Email: hultgren{at}wustl.edu

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