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Research ArticleBIOMOLECULES
Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions
- Vasilios Kalas1,2,3,
- Jerome S. Pinkner1,2,
- Thomas J. Hannan1,2,4,
- Michael E. Hibbing1,2,
- Karen W. Dodson1,2,
- Alex S. Holehouse3,5,
- Hao Zhang6,
- Niraj H. Tolia2,
- Michael L. Gross6,
- Rohit V. Pappu3,5,
- James Janetka6 and
- Scott J. Hultgren1,2,*
- 1Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 3Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 4Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
- 5Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
- 6Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
- ↵*Corresponding author. Email: hultgren{at}wustl.edu
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Science Advances 10 Feb 2017:
Vol. 3, no. 2, e1601944
DOI: 10.1126/sciadv.1601944
Vol. 3, no. 2, e1601944
DOI: 10.1126/sciadv.1601944
Vasilios Kalas
Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jerome S. Pinkner
Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thomas J. Hannan
Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael E. Hibbing
Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Karen W. Dodson
Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Alex S. Holehouse
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Hao Zhang
Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Niraj H. Tolia
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Michael L. Gross
Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Rohit V. Pappu
Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
James Janetka
Department of Chemistry, Washington University in St. Louis, St. Louis, MO 63130, USA.
Scott J. Hultgren
Center for Women’s Infectious Disease Research, Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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