## Abstract

Scientists and inventors can draw on an ever-expanding literature for the building blocks of tomorrow’s ideas, yet little is known about how combinations of past work are related to future discoveries. Our analysis parameterizes the age distribution of a work’s references and revealed three links between the age of prior knowledge and hit papers and patents. First, works that cite literature with a low mean age and high age variance are in a citation “hotspot”; these works double their likelihood of being in the top 5% or better of citations. Second, the hotspot is nearly universal in all branches of science and technology and is increasingly predictive of a work’s future citation impact. Third, a scientist or inventor is significantly more likely to write a paper in the hotspot when they are coauthoring than whey they are working alone. Our findings are based on all 28,426,345 scientific papers in the Web of Science, 1945–2013, and all 5,382,833 U.S. patents, 1950–2010, and reveal new antecedents of high-impact science and the link between prior literature and tomorrow’s breakthrough ideas.

- Social networks
- Knowledge networks
- computational social science
- science of science
- scientimetrics
- human performance

## INTRODUCTION

Scientists and inventors can combine information from an ever-expanding knowledge base dispersed across documents, experiments, and data (*1*). The Web of Science (WOS) contains 28.4 million publications, including more than 1.5 million new articles published in 2014 alone, sextupling the 1970 rate. The U.S. Patent and Trademark Office (USPTO) issued 287,831 patents in 2013, quadrupling the 1970 rate. Although more knowledge enables more novel ideas to be combined (*2*, *3*), scientists and inventors have limited time to search through the expanding base (*4*, *5*). As the rate of knowledge expansion grows, but the time to search for new knowledge remains fixed, scientists and inventors search a smaller fraction of the available knowledge (*6*–*8*). These trade-offs between available knowledge and search costs make understanding where to search for the most valuable past information important to new knowledge advances (*2*, *4*, *7*). However, little research exists on where in the store of knowledge to find the best combinations of past information (*2*).

Consider the following case. Imagine you are in the library of Alexandria in 48 BCE. At the time, the library of Alexandria is the largest store of scientific knowledge on the planet and growing rapidly. Every document related to science, philosophy, or religion written in Egypt is copied and put into the library, as is every document found on every caravan or boat that lands on Egyptian shores. In 48 BCE, the library catches fire. You now have limited time to search for knowledge you think is going to be most valuable for creating the next set of important ideas in your field. How do you search the store of knowledge? Do you gather up the most recent documents under the assumption that they offer a summary statistic of the best of past knowledge? Do you collect the oldest papers that have stood the test of time? Do you look for the papers that were read by the most experts in your field? Do you sample papers at random?

Theories of knowledge development emphasize the importance of past information in the formulation of new ideas (*2*, *9*–*12*) but offer different answers to the questions about where to search for the most fruitful information. One school of thought argues that older work, benefiting from the test of time, is most likely to provide the building blocks of new work, an idea reflected in Isaac Newton’s famous remark, “If I have seen further than others, it is by standing upon the shoulders of giants” (*10*). By contrast, Robert Merton’s births of time theory (*11*) suggests that recent information drives breakthrough ideas (*11*, *12*). Consistent with Merton’s formulation, many information retrieval systems search for recent information first. Cognitively, people tend to retrieve the most recent information first (*13*). Search engines typically return results according to either recency or popularity, both of which correlate with the age of the information (*14*).

Diverging arguments and little empirical study on the information search question have meant that the link between the age of information referenced in a work and a work’s impact remains an open question. Knowing whether old, new, randomly sampled, or popular information is associated with the creation of novel combinations can help provide insight into where the richest combinations of past knowledge are located. To address these questions, we studied modern science and invention to identify the empirical patterns linking the age of information cited in a paper or patent and the paper’s or patent’s subsequent impact.

## RESULTS

We investigated two large domains of knowledge: all 28,426,345 papers in the WOS, 1945–2013, and all 5,382,833 patents published in the U.S. patent office database, 1950–2010. In both domains, the references cited in a work identify the age of the past knowledge it builds upon (*2*, *3*, *5*). To quantify the age of information referenced in a work, we computed the age distribution of its cited references (*6*, *9*). This distribution, denoted *D*, contains the age differences between a work’s publication year and the publication years of its references. Two properties of *D* are its mean (*D*_{μ}) and coefficient of variation (COV) (*D*_{θ}), which we computed for each scientific paper in the WOS and for each U.S. patent. Figure S1 (A and B) shows the empirical distributions of *D*_{μ} and *D*_{θ} for all papers in the WOS in 1995. Figures S2 and S3 (A to C) present null models of referencing behavior and indicate that the observed distributions of *D*_{μ} and *D*_{θ} are not explained by chance. Table S2 shows the measurements of *D*_{μ} and *D*_{θ} for four example papers.

A common measure of the impact of a scientific paper or patent is the number of citations it receives (*2*, *3*, *12*, *15*). We defined a work as high impact (*H* = 1) if a work is in the top 5th percentile of cited works in its scientific or technological subfield based on the citations it accumulated in the first 8 years after publication (*2*, *15*, *16*), and low impact otherwise (*H* = 0). As robustness checks on our measure, we also measured impact as being in the top 1, 10, and 25% of the citation distribution, the log of the number of citations a paper accumulates after 8 years of publication and over its lifetime (*12*, *17*), and a paper’s PageRank of citations, that is, papers with a possibly low number of absolute citations but with relatively many cites from hit papers (*18*). Below, we present the results for papers in the top 5% of the citation distribution. In Materials and Methods, we provide detail on measurements. Robustness checks using other measures of *H* (impact) and *D* (age of knowledge) are presented in the Supplementary Materials (tables S1 and S3 to S9). All measures produced similar results.

### The knowledge hotspot and scientific impact

Figure 1 is a heat plot of the relationship between *D*_{μ}, *D*_{θ}, and *H*. Each point in the plot represents the *D*_{μ} and *D*_{θ} values of papers published in 1995 (*N* = 546,912), and the intensity of the color represents a paper’s probability of high impact. The plot’s vertical and horizontal lines represent the median and mean population-level values of *D*_{μ} and *D*_{θ}. Three main findings are demonstrated. First, amid all the distributions of the ages of information, one type of age distribution is especially associated with high impact. Papers in this “hotspot” have a low *D*_{μ} and high *D*_{θ} and are 2.2 times more likely, on average, to receive citations at a level of 5% or better in their field. Figure 2 further characterizes the knowledge space of papers in the hotspot with respect to time. Papers in the hotspot reference recent ideas in the literature (low average *D*_{μ} = 6.05, SD = 1.74) and ideas of a relatively wide variation of age (high *D*_{θ} = 1.0, SD = 0.23), as revealed by the tail of this distribution, which reaches well into the past at a progressively decreasing rate. Second, papers that center their references on new knowledge—low *D*_{μ} and low *D*_{θ}—have a surprisingly low rate of impact that rarely exceeds what is expected by chance. This suggests that the conventional bias toward heavily citing recent work (*6*) is valuable only when mixed with a high *D*_{θ}. Third, papers that reference prior work centered on older knowledge—that is, papers with high *D*_{μ} and low *D*_{θ} (27% of all papers)—are notable in that they have an *H* that is half the rate expected by chance.

Figure 3 demonstrates that the relationship between the hotspot and level of impact has been remarkably robust across time. Pooling all WOS papers on a year-by-year basis from 1950 to 2005, we find that the information hotspot has invariantly been strongly related to high-impact work for all of modern science. Scientific papers in the hotspot consistently double their chances of being a hit. Further, we observe a growing trend of a paper being a hit when it is in the hotspot. By contrast, papers outside the hotspot have risen and fallen in their relationship to impact but generally remain relatively low impact, with no other mix of *D*_{μ} and *D*_{θ} exceeding the 5% background rate expected by chance. This empirical regularity suggests a fundamental ordering that may characterize the relationship between the age of information referenced in a scientific paper and extraordinary scientific impact.

Figure 4 disaggregates the data in the WOS on a field-by-field basis, revealing a marked similarity across the branches of science with regard to the main findings. The WOS lists 171 subfields in science and engineering, 54 subfields in social sciences, and 27 subfields in arts and humanities. Using the classification for the four types of information search shown in Fig. 1, we computed the fraction of WOS fields for which papers in the hotspot are associated with the highest citation impact. Figure 4 demonstrates that, at the beginning of the postwar era of science, about 60% of fields displayed the “hotspot-hit link” (green bar). By the 2000s, the hotspot overrepresents hit papers in almost 90% of the fields. Thus, despite the large differences between scientific fields in terms of theory, methods, data, and culture, the hotspot dominates the sciences.

To test these patterns in the data while controlling for other variables, we ran fixed-effects regressions to predict the citation impact of individual papers. Fixed-effects regressions allows us to control in a nonparametric and flexible manner for numerous features of each paper, including the predictive capacity of each (i) field, (ii) publication year, (iii) number of references made, and (iv) number of authors. In addition, we control for the degree to which a work references (v) prior work from multiple/interdisciplinary fields, (vi) highly cited papers (*19*), and (vii) conventional and/or novel pairings of prior ideas (*2*). (See Methods for the fixed-effects regression model, the variable construction details, and the related approach used for patents.)

Table 1 shows that the regression models indicate three important relationships between *H*, *D*_{μ}, and *D*_{θ}. First, the knowledge hotspot is strongly related to citation impact net of control variables for time, all 254 scientific fields, and paper-level characteristics. The large drops in the Bayesian information criterion (BIC) statistics when *D*_{μ} and *D*_{θ} are added to the control variable regressions indicate the strong explanatory power of *D*_{μ} and *D*_{θ} (Materials and Methods). Similarly, standardizing the regression coefficients indicates that *D*_{μ} and *D*_{θ} have large substantive effects on citation impact relative to other predictors of citation impact (table S10). Second, Fig. 5 reveals the intricate joint behavior of *D*_{μ} and *D*_{θ} in relation to hit papers. Papers with a high mean age of references (*D*_{μ}) are always associated with a low probability of being a hit irrespective of the variation in the age of references (*D*_{θ}). Conversely, a low mean age of references (*D*_{μ}) is associated with being a hit only when the age variance of references (*D*_{θ}) is high. Papers with a low *D*_{μ} and low *D*_{θ} have surprisingly no greater likelihood of being a hit than expected by chance. Third, the above findings are robust to diverse measures of a hit. Tables S2 to S8 show that the above results are replicated when *H* is measured at the 1st, 10th, 25th, and 50th percentiles of citations, as the log of the number of citations a paper acquires in its first 8 years after publication, citations acquired over a paper’s lifetime, a paper’s PageRank (*18*), or whether a paper receives the bulk of its citations long after its year of publication, that is, “sleeping beauties” (*17*).

### The knowledge hotspot and patenting impact

Like scientific papers, patent impact is measured by citations received, and their references indicate the prior literature the new patent is based on (*3*, *20*). In patenting, the patent examiner’s official obligation is to augment authors’ citations by citing relevant work authors miss and minimizing irrelevant citations and strategic citations (*21*). Further, patent examiners assign references after seeing the submitted patent. Thus, their retrospective citation process helps identify the knowledge space applicable to a patent.

Patents have the same hotspot-hit relationship as scientific papers. Figure 6 indicates that patents that are in the hotspot are significantly overrepresented at the 5% level of impact. Like papers, patents in the hotspot reference some recent patents (low average *D*_{μ} = 6.08, SD = 1.75) and papers of a relatively wide variation of age (high *D*_{θ} = 0.98, SD = 0.22). Figure 6 shows that the same hotspot-hit paper relationship holds on an annual basis for patents. Figure 6 indicates that the hotspot is consistently overrepresented in relation to hit patents in 95 to 100% of the patenting subfields over our time frame of 30 years. Tables S11 and S12 present fixed-effects regressions confirming these results net of controls, indicating that the hotspot-hit relationship is robust for inventors and technology and that two critical knowledge creation domains share surprisingly similar and nearly universal patterns relating the age distribution of the referenced literature in a work and a work’s probability of being a hit.

### Search and the hotspot

The nearly universal benefit linked to the hotspot in science and patenting raises a question as to the factors related to authoring work in versus out of the hotspot. Previous work has found a link between teamwork in science and a paper’s citation impact (*2*, *22*, *23*). However, the mechanisms behind the team effect and whether the same scientist performs better working alone or in teams remain unknown (*9*, *12*, *24*–*26*). One conjecture is that collaboration potentially reduces knowledge search and awareness problems that solo authors face (*2*, *27*). We examined authors and inventors who created works on their own and in collaboration with others and tested whether the same author is more or less likely to write papers that are in the hotspot when authoring alone versus coauthoring with others. The data used in this analysis comes from two sources: all Fields Medalists in mathematics and patentees. Fields Medalists offer a conservative test of the collaboration conjecture. If collaboration helps augment the search capabilities of individual scientists, then exceptional scientists may be least likely to receive a boost from collaboration. Patentees provide a test of the collaboration conjecture for all patentees in the U.S. patent database. (Note: We could not analyze all WOS authors because WOS author names lack disambiguation.) Using these data sets, we implement regressions that include fixed effects for each individual author. This approach estimates a within-subject design (rather than a between-subject design), treating each author as her own control case and accounting flexibly for the author’s fixed characteristics (for example, IQ, training, and personality). The regression estimates the increase in the probability of a given author producing a paper in the hotspot versus outside the hotspot as a function of whether a given author worked alone or collaborated with others. The regression additionally has fixed effects controls for field, year, and number of references. (See Methods for the regression model and variable construction details.)

Figure 7 graphically presents the results for Fields Medalists. More than 80% of Fields Medalists are significantly more likely to have papers in the hotspot when coauthoring than when writing a paper alone, a relationship unlikely to happen by chance (*P* < 0.00009, binomial test). Consistent with our main effects, Fields Medalists’ papers in the hotspot are twice as likely to be their most cited papers on average, reinforcing our general result. Examining patentees, we found a comparable increase in the probability of being in the hotspot associated with collaboration. Collaboration significantly (*P* < 0.0001) improves the likelihood of inventors writing patents that are in the hotspot (table S13).

## DISCUSSION

Scientists and inventors prospect an ever-expanding knowledge space in pursuit of new ideas and discoveries. More knowledge suggests more creative material to draw upon, but scientists and inventors are limited in their capacity to search through the knowledge space. This search trade-off puts a premium on knowing where to search in the literature to discover the most valuable building blocks of new knowledge.

Some theories of knowledge emphasize the importance of using and combining recent ideas in driving breakthroughs, whereas others purport that past knowledge that has withstood the test of time is most valuable (*10*–*12*). Our findings show that each approach is only partly correct. Drawing narrowly on recent ideas does not lead to exceptional impact. Similarly, drawing on vintage knowledge or widely sampled work is associated with an impact no greater than expected by chance.

We find a subtler yet nearly universal pattern that links the age of past knowledge to high-impact work. Our work indicates that a knowledge hotspot characterizes a distribution of the age of prior literature referenced by a paper, relative to the paper’s publication year, that is associated with exceptionally high impact in science and technology. Papers and patents in the hotspot reference literature with a low mean age and high age variance relative to a work’s publication year. Works in the hotspot more than double their probability of being in the top 5% of impact in their field. Works outside of the hotspot—work centered on recent papers, old papers, or a broad sample of new and old works—do no better than expected by chance. The hotspot’s significance is further highlighted by the fact that the highest-impact works across scientific and patenting fields have a similar hotspot-hit relationship. Beyond science and technology, work in progress indicates that the hotspot also reflects the relationship between past and future knowledge in law. In other work, we found that Supreme Court rulings in the United States, Canada, and India that are in the hotspot are overrepresented among the most influential laws (*28*). Last, the hotspot is becoming increasingly predictive of high-impact work over time and now appears in nearly all subfields of science and technology.

The hotspot’s generality indicates that there is an age distribution of prior knowledge that is particularly linked to tomorrow’s breakthroughs. Future research should begin to investigate what is unique about the knowledge that follows this distribution. Consider two papers written at the same time on the same topic but one paper is in the hotspot and the other is not. What ideas does the former paper have that are not found in the knowledge space searched by the later paper? One conjecture is that the nature of scientific and technological progress involves new knowledge absorbing, replacing, or improving upon prior knowledge. However, these processes may often take time before critical tests can be conducted, debates can be settled, funds can be garnered for addressing the biggest problems and for a large community of scholars to form around the problem. Thus, although a narrow focus on recent literature may offer an opportunity to capitalize on the latest ideas, the research may turn out to be a fad or dead end. At the same time, a narrow focus on vintage work may fail to connect classic ideas with current problems or insights.

Why is it that 75% of the papers and patents are outside the hotspot? We found that one determinant of being in the hotspot is related to collaboration: Authors are more likely to produce work that is in the hotspot when coauthoring than when working alone. Why teams are associated with higher impact work is still an open question and may be related to several explanations that still need to be tested, including a division of labor, collective intelligence, benefits of specialization, positive competition among teammates, myopic search, and social support (*29*). Our findings provide a new explanation for the correlation found between team science and impact with a focus on the role teams play in searching complex knowledge spaces. Amidst these new questions and directions for future work, our findings reveal that the age of information is a remarkably powerful and heretofore unknown predictor of high-impact work in science and technology.

## MATERIALS AND METHODS

### Data sources used in the analyses

**Scientific papers database**

We examined all 28,426,345 research articles indexed in the Thomson Reuters WOS database that were published from 1945 to 2013. The subfield designation of science and engineering (171 subfields), social sciences (54 subfields), and arts and humanities (27 subfields) was defined by the WOS and covers research publications in science and engineering since 1945, social sciences since 1956, and arts and humanities since 1975. These data are described in the Supplementary Materials and are available from Thomson Reuters.

**Patents database**

We studied all 5,382,833 patents granted by the USPTO between 1950 and 2010. The data are described in detail in the Supplementary Materials and are available from https://iu.app.box.com/patents/1/779886700/7307669062/1, https://iu.app.box.com/patents/1/779886700/15411270285/1, and https://dataverse.harvard.edu/dataverse/patent. See the Supplementary Materials for further details.

**Fields Medalist database**

We collected the data on all 31 mathematicians who won the Fields Medal between 1954 and 2006. This time period allowed us to have at least 8 years of forward and backward citation data for the Fields Medalists’ papers. Data are located at http://ams.org/mathscinet/search/author.html?mrauthid=%s&Submit=Search. See the Supplementary Materials for further details.

### Measures

**High-impact scientific papers and patents (“hits”)**

We measured a work’s *H* for our main results based on the number of times it was cited in the first 8 years of publication in its respective subfield of science (*6*, *18*, *21*, *22*, *30*). A work with high impact was defined as being in the top 5% of cited works in its specific subfield (that is, 1 of 252 subfields) and year of publication. To test the robustness of our measures, we described many alternative measures and tests of *H* in the Supplementary Materials, all of which produced results that are in agreement with the ones reported in the main text. The alternative measures were hits defined as being in the top 1, 10, and 25% of the citation distribution, the log of the number of citations a paper accumulates after 8 years of publication and over its lifetime, and a paper’s PageRank of citations, that is, papers with a low number of absolute citations but with relatively many cites by hit papers (*18*) and “sleeping beauty” papers (papers that receive the bulk of their citation long after the year of their publication) (*17*). All tests of alternative measures produced confirmatory results.

**Age of referenced knowledge**

For each paper and patent, we measured (i) the average age of references, *D*_{μ}, and (ii) the COV of the age of references, *D*_{θ}. Specifically, *D*_{μ} is the mean duration in years between a work’s publication year and the publication years of the documents it references (*6*). For example, in fig. S2A, we considered a paper published in 1995 and referencing prior works published in 1990, 1988, 1987, and 1985; this paper has a *D*_{μ} of 7.5 (the mean of 5, 7, 8, and 10 years between the publication year and reference years). A work with relatively small *D*_{μ} references relatively recent work. In the preceding example, *D*_{θ} is 0.308 (SD of 2.16 years normalized by the mean of 7.5 years). A work with a low *D*_{θ} references knowledge that is relatively narrowly dispersed around its mean value. Note that a paper’s age distribution of references can have a low *D*_{μ} and high *D*_{θ} whenever the focal paper and most of its references are published close in time, but a few references are published many years before the focal paper. When the focal paper and its references are published close in time, the paper has a low mean age (*31*). When a paper has a low mean age but a small share of its references were published years before the focal paper, the SD and the COV become large, producing papers that have a low mean age and a high age variance, as shown in Fig. 1. About four percent of all papers had a zero difference between their publication year and reference years and were omitted from the analysis. (Please see the Supplementary Materials for a case example, numerical simulations that generalize the case examples, and further details.) For papers published between 1950 and 2000, the mean and SD of *D*_{θ} and *D*_{μ} are 0.731 and 0.239, and 8.482 and 4.293, respectively. For patents published between 1980 and 2000, the mean and SD of *D*_{θ} and *D*_{μ} are 0.549 and 0.287, and 12.323 and 8.563, respectively. To test the robustness of measures *D*_{θ}, *D*_{μ}, and *H*, we showed the results for alternative measures of the age of information in the Supplementary Materials, all of which are in agreement with the results reported in the main text (tables S1 and S3 to S9).

### Methods

**Fixed-effects regressions: Predicting citation impact**

For predicting citation impact, the regression for scientific papers takes the formand the regression for patents takes the form

To isolate the effects of our main variables from other predictors of *H* (*6*, *15*, *19*, *25*, *32*–*34*), we ran logistic regression models, where we regressed *H* on our main explanatory variables *D*_{μ} and *D*_{θ}. Control variables include those specific to a paper or patent (work *i*) and fixed effects that are specific to categories in the data. The set of control variables varies slightly between papers and patents given data availability, as defined below.

Dependent variable: Citation impact, *H* (*H* = 1 if a paper or patent is in the top 5% percentile of citations as defined above; 0 otherwise)

Predictor variables: *D*_{μ} and *D*_{θ}.

**Control variables used in the regression analyses**

*p*_{i} measures the degree to which work *i* references prior work from multiple/interdisciplinary fields. To operationalize this variable, we assigned each pair of references in work *i*’s bibliography a value of 1 if the pairs are from the same discipline (as defined by the WOS or USPTO) and 0 otherwise. We then took the average across all reference pairs in a bibliography to compute work *i*’s interdisciplinarity, which varies from 0 to 1. Global means (SDs) are 0.652 (0.208) for papers and 0.655 (0.339) for patents.

*a*_{i} measures the degree to which a paper *i* references prior work that represents novel pairings of prior ideas and is operationalized using the measures described by Evans (*6*). Global means (SDs) are 0.331 (0.470) for papers and not available for patents.

*c*_{i} measures the degree to which a paper *i* references prior work that represents conventional pairings of prior ideas and is operationalized using the measures described by Evans (*6*). Global means (SD) are 4.237 (1.598) for papers and not available for patents.

*m*_{i} measures the degree to which work *i* references highly cited papers (*2*). To control for possible differences in the quality of referenced information, we computed the mean number of citations accumulated by all the references in work *i*’s bibliography. For example, if work *i* references a total of three papers that have accumulated 10, 5, and 30 citations, then *m*_{i} is equal to 15 (45 citations/3 references). Global means (SDs) are 70.561 (144.586) for papers and 8.759 (11.220) for patents.

**Fixed-effects controls**

*N* controls for the number of authors on work *i* (*18*, *28*). We included indicator variables for one, two, and three or more authors. In the regressions, the omitted indicator variable was for solo authorship.

*Y* controls for time fixed effects, that is, features of the data that are constant within a year but vary across years such as number of papers published, cohort, annual amount of funding awarded, number of scientists or patentees, and so on. We created an indicator variable for each year, where 2000 was the omitted year for the regression model for papers (1950–2000) and patents (1980–2000).

*R* controls for the total number of references in work *i*’s bibliography. We created 10 indicator variables (1 = yes; 0 otherwise) for 10 different categories of reference counts. Category 1 has a range of references from 0 to 10, category 2 has a range of references from 11 to 20, etc., with the final category representing 90 references or above. Using 10 equally sized percentile groupings produced the same results. In the regressions, the omitted indicator variable was for category 1. Global means (SDs) are 23.814 (18.439) for papers and 8.656 (10.442) for patents.

*S* controls for fixed differences across scientific or patenting fields, which include differences between fields in the number of journals, norms of production, topics, and so on. We created an indicator variable for each of the 252 subfields of science and the 36 subfields of patenting. In the regressions, the omitted field indicators were *AA* (subfield of “acoustics” as indexed in WOS) and 11 (subfield of “agriculture, food, and textiles” for patents).

**Fixed-effects regressions: Predicting work in hotspot**

To predict work in the hotspot versus outside of the hotspot, we used the following fixed-effects model

Dependent variable: *h*_{i} (*h*_{i} = 1 if a paper or patent is in hotspot; 0 otherwise)

Predictor variable: *n*_{i} (*n*_{i} = 1 if the paper/patent is solo-authored; 0 otherwise)

**Control variables used in the regression analyses**

*Q* controls for name (in Fields Medalists) or name ID (in patents) fixed effects. We created an indicator variable for every Fields Medalist and patent inventor. This approach means that the regression tells us whether a given individual tends to produce work in the hotspot when that person collaborates with others compared to instances where that same individual works alone. Other control variables in this regression (*Y*, *R*, and *S*) are defined above.

**BIC goodness-of-fit statistics for the regression analyses**

BIC statistics were used to interpret the improvement in fit of the regression model when *D*_{μ} and *D*_{θ} were added to the control variable model (*25*). In all models, the drop in the BIC statistics greatly exceeded 10, indicating that there is “strong evidence” that *D*_{μ} and *D*_{θ} provide a significantly and substantively better fit to the data than does the control variable model [(*25*), p. 139]. Specifically, the values of BIC goodness-of-fit statistics for analyses with and *D*_{μ} and *D*_{θ} are as follows:

## SUPPLEMENTARY MATERIALS

Supplementary material for this article is available at http://advances.sciencemag.org/cgi/content/full/3/4/e1601315/DC1

section S1. Data sets

section S2. *D*_{μ} and *D*_{θ} distributions

section S3. Alternative measures of *D*_{θ} produce equivalent results

section S4. Simple null model of referencing with respect to the age of a publication or patent

section S5. Demonstration case

section S6. Robustness checks for alternative measures of being a hit beyond the top 5% (top 1, 10, 25, and 50%) for papers

section S7. Further robustness checks

section S8. Standardized coefficients of papers

section S9. Regression analyses of patents

section S10. Predicting referencing in the hotspot

section S11. BIC statistics for supplemental regression analyses

fig. S1. Reference age distributions.

fig. S2. Switching references in the null model.

fig. S3. Expected and observed distributions of reference age distributions.

table S1. Alternative measures of *D*_{θ} produce consistent results.

table S2. Demonstration case of search and impact.

table S3. Probability of being in the top 1% of citations for papers.

table S4. Probability of being in the top 10% of citations for papers.

table S5. The probability of being in the top 25% of citations for papers.

table S6. The probability of being in the top 50% of citations for papers.

table S7. The probability of being a sleeping beauty paper at different levels of citations.

table S8. Fixed-effects ordinary least squares regression estimating the relationship between *D*_{μ} and *D*_{θ} and the citations acquired in the first 8 years after publication and for all citations over a paper’s lifetime.

table S9. Approximate PageRank analysis.

table S10. Standardized coefficients of the probability of being in the top 5% of papers.

table S11. Probability of being in the top 5% of citations for patents.

table S12. Probability of being in the top 1% of citations for patents.

table S13. Probability of a paper referencing work in the knowledge hotspot for coauthors versus solo authors.

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is **not** for commercial advantage and provided the original work is properly cited.

## REFERENCES AND NOTES

**Acknowledgments:**We thank A. Pah, S. Saavedra, C. Huepe, A. Horvát, and J. Poncela for their helpful comments.

**Funding:**This research was funded by grants from the Northwestern University Clinical and Translational Sciences Institute, the Northwestern University Institute for Complex Systems, and the Multidisciplinary University Research Initiative–Defense Advanced Research Projects Agency (DARPA) (grant BAA-11-64). The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the social policies, either expressed or implied, of DARPA or the U.S. government.

**Author contributions:**S.M. conducted data collection and analysis, designed analyses, and wrote the paper. D.M.R. conducted data analysis, designed analyses, and wrote the paper. B.J. designed analyses and wrote the paper. B.U. conducted data collection and analysis, designed analyses, wrote the paper, and received grant funding.

**Competing interests:**The authors declare that they have no competing interests.

**Data and materials availability:**All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials and are available online through the WOS. Additional data related to this paper may be requested from the authors.

- Copyright © 2017, The Authors