Research ArticleNEUROSCIENCE

Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7

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Science Advances  05 Apr 2017:
Vol. 3, no. 4, e1602663
DOI: 10.1126/sciadv.1602663

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Abstract

Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian brain-type fatty acid binding protein (Fabp7) is expressed in astrocytes, and its mRNA oscillates in tandem with the sleep-wake cycle. However, the role of FABP7 in regulating sleep remains poorly understood. We found that the missense mutation FABP7.T61M is associated with fragmented sleep in humans. This phenotype was recapitulated in mice and fruitflies bearing similar mutations: Fabp7-deficient mice and transgenic flies that express the FABP7.T61M missense mutation in astrocytes also show fragmented sleep. These results provide novel evidence for a distinct molecular pathway linking lipid-signaling cascades within astrocytes in sleep regulation among phylogenetically disparate species.

Keywords
  • sleep
  • gene
  • Evolution
  • astrocyte
  • glia
  • sleep fragmentation
  • BLBP
  • B-FABP
  • missense
  • polymorphism

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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