Research ArticleNEUROSCIENCE

Serotonin rebalances cortical tuning and behavior linked to autism symptoms in 15q11-13 CNV mice

See allHide authors and affiliations

Science Advances  21 Jun 2017:
Vol. 3, no. 6, e1603001
DOI: 10.1126/sciadv.1603001

You are currently viewing the abstract.

View Full Text

Abstract

Serotonin is a critical modulator of cortical function, and its metabolism is defective in autism spectrum disorder (ASD) brain. How serotonin metabolism regulates cortical physiology and contributes to the pathological and behavioral symptoms of ASD remains unknown. We show that normal serotonin levels are essential for the maintenance of neocortical excitation/inhibition balance, correct sensory stimulus tuning, and social behavior. Conversely, low serotonin levels in 15q dup mice (a model for ASD with the human 15q11-13 duplication) result in impairment of the same phenotypes. Restoration of normal serotonin levels in 15q dup mice revealed the reversibility of a subset of ASD-related symptoms in the adult. These findings suggest that serotonin may have therapeutic potential for discrete ASD symptoms.

Keywords
  • autism spectrum disorder
  • mouse model
  • CNV
  • serotonin
  • behavior
  • 15q duplication

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

View Full Text