Research ArticleGENOME SEQUENCING

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

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Science Advances  04 Aug 2017:
Vol. 3, no. 8, eaao0027
DOI: 10.1126/sciadv.aao0027

Article Information

vol. 3 no. 8

Online ISSN: 
History: 
  • Received for publication June 1, 2017
  • Accepted for publication July 6, 2017

Author Information

  1. Yavuz S. Dagdas1,*,
  2. Janice S. Chen2,*,
  3. Samuel H. Sternberg3,,
  4. Jennifer A. Doudna2,3,4,5, and
  5. Ahmet Yildiz2,6,
  1. 1Biophysics Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA.
  2. 2Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
  3. 3Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.
  4. 4Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
  5. 5Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
  6. 6Department of Physics, University of California, Berkeley, Berkeley, CA 94720, USA.
  1. Corresponding author. Email: yildiz{at}berkeley.edu (A.Y.); doudna{at}berkeley.edu (J.A.D.)
    • * These authors contributed equally to this work.

    • Present address: Caribou Biosciences Inc., Berkeley, CA 94710, USA.

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