Research ArticleHEALTH AND MEDICINE

Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons

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Science Advances  10 Oct 2018:
Vol. 4, no. 10, eaat5847
DOI: 10.1126/sciadv.aat5847

Article Information

vol. 4 no. 10

Online ISSN: 
History: 
  • Received for publication March 14, 2018
  • Accepted for publication September 5, 2018

Author Information

  1. Tatsuya Osaki1,
  2. Sebastien G. M. Uzel1,2,3 and
  3. Roger D. Kamm1,4,5,*
  1. 1Department of Mechanical Engineering, Massachusetts Institute of Technology, 500 Technology Square, Room NE47-321, Cambridge, MA 02139, USA.
  2. 2Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
  3. 3John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
  4. 4Department of Biological Engineering, Massachusetts Institute of Technology, 500 Technology Square, Room NE47-321, Cambridge, MA 02139, USA.
  5. 5BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore.
  1. *Corresponding author. Email: rdkamm{at}mit.edu

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