Research ArticleORGANISMAL BIOLOGY

HEx: A heterologous expression platform for the discovery of fungal natural products

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Science Advances  11 Apr 2018:
Vol. 4, no. 4, eaar5459
DOI: 10.1126/sciadv.aar5459

Article Information

vol. 4 no. 4

Online ISSN: 
History: 
  • Received for publication November 20, 2017
  • Accepted for publication February 26, 2018

Author Information

  1. Colin J. B. Harvey1,*,,,
  2. Mancheng Tang2,,
  3. Ulrich Schlecht1,
  4. Joe Horecka1,
  5. Curt R. Fischer1,3,
  6. Hsiao-Ching Lin2,
  7. Jian Li1,
  8. Brian Naughton1,*,
  9. James Cherry1,
  10. Molly Miranda1,
  11. Yong Fuga Li1,§,
  12. Angela M. Chu1,
  13. James R. Hennessy1,
  14. Gergana A. Vandova1,
  15. Diane Inglis4,
  16. Raeka S. Aiyar1,
  17. Lars M. Steinmetz1,4,5,
  18. Ronald W. Davis1,4,
  19. Marnix H. Medema6,
  20. Elizabeth Sattely7,
  21. Chaitan Khosla3,7,8,
  22. Robert P. St. Onge1,
  23. Yi Tang2,9 and
  24. Maureen E. Hillenmeyer1,*,
  1. 1Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
  2. 2Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
  3. 3Stanford ChEM-H (Chemistry, Engineering and Medicine for Human Health), Stanford University, Palo Alto, CA 94304, USA.
  4. 4Department of Genetics, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
  5. 5European Molecular Biology Laboratory Heidelberg, 69117 Heidelberg, Germany.
  6. 6Bioinformatics Group, Wageningen University, Wageningen, Netherlands.
  7. 7Department of Chemical Engineering, Stanford University, Palo Alto, CA 94304, USA.
  8. 8Department of Chemistry, Stanford University, Palo Alto, CA 94304, USA.
  9. 9Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
  1. Corresponding author. Email: maureenh{at}stanford.edu (M.E.H.); cjharvey{at}stanford.edu (C.J.B.H.)
    • * Present address: Hexagon Bio, Menlo Park, CA 94025, USA.

    • These authors contributed equally to this work.

    • § Present address: Department of Bioinformatics, Illumina Inc., San Diego, CA 92122, USA.

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