Research ArticlePHYSIOLOGY

Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans

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Science Advances  22 Aug 2018:
Vol. 4, no. 8, eaar8590
DOI: 10.1126/sciadv.aar8590

Article Information

vol. 4 no. 8

Online ISSN: 
  • Received for publication December 25, 2017
  • Accepted for publication July 18, 2018

Author Information

  1. Jonathan Cedernaes1,*,
  2. Milena Schönke2,,
  3. Jakub Orzechowski Westholm3,,
  4. Jia Mi4,5,
  5. Alexander Chibalin2,
  6. Sarah Voisin1,
  7. Megan Osler2,
  8. Heike Vogel6,
  9. Katarina Hörnaeus4,
  10. Suzanne L. Dickson7,
  11. Sara Bergström Lind4,
  12. Jonas Bergquist4,8,9,
  13. Helgi B Schiöth1,
  14. Juleen R. Zierath2 and
  15. Christian Benedict1
  1. 1Department of Neuroscience, Uppsala University, Uppsala, Sweden.
  2. 2Department of Molecular Medicine and Surgery, Karolinska Institutet, Solna, Sweden.
  3. 3Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
  4. 4Department of Chemistry–BMC, Uppsala University, Uppsala, Sweden.
  5. 5Medicine and Pharmarcy Research Center, Binzhou Medical University, Yantai, China.
  6. 6Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany.
  7. 7Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  8. 8Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA.
  9. 9Precision Medicine, Binzhou Medical University, Yantai, China.
  1. *Corresponding author. Email: jonathan.cedernaes{at}
    • These authors contributed equally to this work.


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