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A plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease

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Science Advances  06 Feb 2019:
Vol. 5, no. 2, eaau7220
DOI: 10.1126/sciadv.aau7220

Article Information

vol. 5 no. 2

Online ISSN: 
History: 
  • Received for publication July 9, 2018
  • Accepted for publication December 19, 2018

Author Information

  1. Nicholas J. Ashton1,2,3,4,
  2. Alejo J. Nevado-Holgado5,
  3. Imelda S. Barber5,
  4. Steven Lynham6,
  5. Veer Gupta7,8,9,
  6. Pratishtha Chatterjee7,10,11,
  7. Kathryn Goozee10,11,12,13,
  8. Eugene Hone7,8,
  9. Steve Pedrini7,8,
  10. Kaj Blennow3,14,
  11. Michael Schöll3,4,
  12. Henrik Zetterberg3,14,15,16,
  13. Kathryn A. Ellis17,
  14. Ashley I. Bush8,18,
  15. Christopher C. Rowe19,
  16. Victor L. Villemagne19,
  17. David Ames17,20,
  18. Colin L. Masters18,
  19. Dag Aarsland1,2,21,
  20. John Powell1,2,
  21. Simon Lovestone5,
  22. Ralph Martins7,8,10,11 and
  23. Abdul Hye1,2,*
  1. 1King’s College London, Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London, UK.
  2. 2NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK.
  3. 3Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
  4. 4Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
  5. 5Department of Psychiatry, University of Oxford, Oxford, UK.
  6. 6Proteomics Core Facility, James Black Centre, King’s College, London, UK.
  7. 7School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia.
  8. 8Cooperative Research Centre for Mental Health, Carlton South, VIC, Australia.
  9. 9School of Medicine, Faculty of Health, Deakin University, 3220 VIC, Australia.
  10. 10KaRa Institute of Neurological Diseases, Macquarie Park, NSW, Australia.
  11. 11Department of Biomedical Sciences, Macquarie University, 2109, NSW, Australia.
  12. 12Clinical Research Department, Anglicare, Sydney, NSW, Australia.
  13. 13School of Psychiatry and Clinical Neurosciences, University of Western Australia, WA, Australia.
  14. 14Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
  15. 15Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK.
  16. 16UK Dementia Research Institute at UCL, London, UK.
  17. 17Academic Unit for Psychiatry of Old Age, St. George’s Hospital, University of Melbourne, VIC, Australia.
  18. 18The Florey Institute, University of Melbourne, VIC, Australia.
  19. 19Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, VIC, Australia.
  20. 20National Ageing Research Institute, Parkville, VIC, Australia.
  21. 21Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
  1. *Corresponding author. Email: abdul.1.hye{at}kcl.ac.uk

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