Science Advances

Supplementary Materials

This PDF file includes:

  • Legends for tables S1 to S9
  • Fig. S1. Hi-C interaction matrices for the q arm of chromosome 2.
  • Fig. S2. Hi-C interaction matrices for the q arm of chromosome 3.
  • Fig. S3. Hi-C interaction matrices for the q arm of chromosome 4.
  • Fig. S4. Hi-C interaction matrices for the p arm of chromosome 4.
  • Fig. S5. Genomic feature analysis of contact probability.
  • Fig. S6. Comparison of first and second Hi-C experiments.
  • Fig. S7. Characteristics of TADs and A and B compartments.
  • Fig. S8. Representative genes that switch compartments.
  • Fig. S9. Physical distances between individual loci within a single chromosome
    arm.
  • Fig. S10. Quantification of comet assay images.
  • Fig. S11. Measurement of chromosome arm volumes.
  • Fig. S12. Measurement of centromere and telomere volumes in senescent cells.
  • Fig. S13. Comparison of Hi-C data between replicative senescence and oncogene-induced senescence.
  • Fig. S14. High-resolution comparison of Hi-C data between replicative
    senescence and oncogene-induced senescence.
  • Legends for movies S1 and S2

Download PDF

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Sequencing and iterative alignment statistics
    for Hi-C experiments.
  • Table S2 (Microsoft Excel format). Resampling statistics for Hi-C experiments.
  • Table S3 (Microsoft Excel format). Overlap of switching TADs with ENCODE
    regulatory elements.
  • Table S4 (Microsoft Excel format). Compartment switching gene sets
    corresponding to Fig. 3D.
  • Table S5 (Microsoft Excel format). GSEA summary statistics for compartment
    switching gene sets.
  • Table S6 (Microsoft Excel format). Overlap of compartment switching genes with
    gene sets of senescence-associated phenotypes.
  • Table S7 (Microsoft Excel format). FISH probes used for 3D DNA-FISH
    experiments.
  • Table S8 (Microsoft Excel format). Summary statistics for 3D DNA-FISH
    experiments.
  • Table S9 (Microsoft Excel format). Sanger sequencing validation of quiescent and
    senescent Hi-C libraries.
  • Movie S1 (.mp4 format). Rotating movie of the 3D Hi-C model for chromosome
    18 in quiescent (left structure) and senescent cells (right structure).
  • Movie S2 (.mp4 format). Rotating movie of the 3D Hi-C model for chromosome
    4 quiescent (left structure) and senescent cells (right structure).

Files in this Data Supplement: