Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Correlations of cfDNA with epididymal fat weight, liver and blood glucose level.
  • Fig. S2. Adipocyte degeneration induced by a high-fat diet.
  • Fig. S3. Effects of TLR9 agonist and antagonist on MCP-1 expression in macrophages.
  • Fig. S4. Effects of TLR9 agonist and antagonist on Tlr9−/− macrophages.
  • Fig. S5. Release of cfDNA from TNF-α–treated adipocytes.
  • Fig. S6. Expression of Tlr2, Tlr4, and Tlr7 in Tlr9−/− macrophages.
  • Fig. S7. Effects of TLR9 antagonist on macrophages treated with cfDNA.
  • Fig. S8. Level of obesity between Tlr9−/− mice and wild-type mice.
  • Fig. S9. Comparison of blood glucose and serum insulin levels between wild-type mice and Tlr9−/− mice.
  • Fig. S10. Food consumption and metabolic studies of mice.
  • Fig. S11. Insulin signaling in VAT obtained from fat-fed mice.
  • Fig. S12. Comparison between Tlr9−/− mice and wild-type mice fed NC.
  • Fig. S13. Level of obesity between BMT mice and non-BMT mice fed a high-fat diet.
  • Fig. S14. Replacement rate of BM cells after transplantation.
  • Fig. S15. Detection of bacterial DNA in plasma cfDNA.
  • Table S1. Comparison between Tlr9−/− mice and wild-type mice.
  • Table S2. Comparison between BM chimeric mice.
  • Table S3. Comparison between iODN2088 and control for iODN-treated wild-type mice.
  • Table S4. Multivariate analysis estimating HOMA-IR.
  • Table S5. Primer sequences.

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