Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. ATPase activity of purified, recombinant mouse P-gp.
  • fig. S2. Functional expression of mouse P-gp in yeast cells.
  • fig. S3. Comparison of PBDE-100 interacting residues.
  • fig. S4. Amino acid sequence alignment of human, mouse, zebrafish, and sea urchin P-gp.
  • fig. S5. Levels of POPs in wild-caught yellowfin tuna.
  • fig. S6. Individual POP congeners from the mixture inhibiting human P-gp.
  • table S1. Data collection and refinement statistics of the mouse P-gp/PBDE-100 cocrystal structure.
  • table S2. Metadata on yellowfin tuna specimens used in this study.
  • table S3. Physical and chemical properties of the 10 POP inhibitors.
  • References (89–94)

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