Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • fig. S1. Loss of PRC1 induces a differentiated phenotype in Lin transformed cells.
  • fig. S2. Loss of PRC1 induces a differentiated phenotype independently of Cdkn2a expression.
  • fig. S3. Specificity check of H2AK119Ub signal.
  • fig. S4. Loss of PRC1 activity induces leukemic cell differentiation.
  • fig. S5. Loss of PRC1 activity negatively affects the growth of primary leukemia both in vitro and in vivo.
  • fig. S6. Bmi1 knockdown does not recapitulate the Ring1a/b-deficient phenotype.
  • Legends for tables S1 to S4
  • References (3640)

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Other Supplementary Material for this manuscript includes the following:

  • table S1 (Microsoft Excel format). ChIP-seq results in Lin and leukemic cells.
  • table S2 (Microsoft Excel format). Genome-wide expression in wild-type, PRC1 Lin, and leukemic cells.
  • table S3 (Microsoft Excel format). Genome-wide expression in primary MLLAF9 leukemic cells.
  • table S4 (Microsoft Excel format). ChIP-seq results in primary MLL-AF9 leukemic cells.

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