Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Structural analysis of solved FimGNteH complex crystal structures.
  • fig. S2. Structural comparison of all known FimH conformations.
  • fig. S3. Solution analysis of FimCH and FimGNteH variants.
  • fig. S4. Native and ion mobility mass spectra of FimGNteH variants in the absence or presence of 4Z269.
  • fig. S5. Conformational dynamics and binding mechanisms of FimGNteH WT.
  • table S1. Data collection and refinement statistics.
  • table S2. Fitted parameter values and analysis of Gaussian peaks on CCS distributions.
  • Legends for movies S1 to S8

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Other Supplementary Material for this manuscript includes the following:

  • movie S1 (.mpg format). Combined MD simulation trajectories initiated from the T state in the absence of mannose.
  • movie S2 (.mpg format). Combined MD simulation trajectories initiated from the bent R state in the absence of mannose.
  • movie S3 (.mpg format). Combined MD simulation trajectories initiated from the elongated R state in the absence of mannose.
  • movie S4 (.mpg format). Combined MD simulation trajectories initiated from the T state in the presence of mannose.
  • movie S5 (.mpg format). Combined MD simulation trajectories initiated from the bent R state in the presence of mannose.
  • movie S6 (.mpg format). Combined MD simulation trajectories initiated from the elongated R state in the presence of mannose.
  • movie S7 (.mpg format). Combined MD simulation trajectories initiated from the T state in the presence of oligomannose-3.
  • movie S8 (.mpg format). Combined MD simulation trajectories initiated from the bent R state in the presence of oligomannose-3.

Download Movies S1 to S8

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