Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Structure-based multiple sequence alignment of 2C proteins from different enteroviruses.
  • fig. S2. Structure of three-liganded zinc finger of EV71 2C.
  • fig. S3. SAXS experiments of various EV71 2C with mutations or deletions at pocket-binding motifs.
  • fig. S4. Circular dichroism spectroscopy of EV71 2C mutants and truncations.
  • fig. S5. Structure of ATP-binding site of EV71 2C.
  • fig. S6. Model of the C terminus of EV71 2C bound to 3C proteinase.
  • fig. S7. Structural comparison of 2C-2C interactions.
  • table S1. Data collection and refinement statistics.
  • table S2. Parameters in SAXS experiments.

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