Science Advances

Supplementary Materials

This PDF file includes:

  • table S1. Number of amino acids and sequence identity between the respective capsid proteins in HAdV-D26 and HAdV-C5.
  • table S2. Residues forming the HVRs in HAdV-D26 versus HAdV-C5.
  • table S3. Structural characteristics and interactions of the N and C termini of hexon subunits in HAdV-D26.
  • table S4. Fiber-PB interactions in HAdV-D26.
  • table S5. Protein IIIa interactions with the major and minor proteins in HAdV-D26.
  • table S6. Data collection and refinement statistics of HAdV-D26.
  • fig. S1. Resolution estimations of the cryo-EM reconstruction of HAdV-D26.
  • fig. S2. Estimation of local resolution of the HAdV-D26 cryo-EM reconstruction.
  • fig. S3. Structural similarities and differences between the hexon subunits of HAdV-D26 and HAdV-C5.
  • fig. S4. Structural similarities and differences between the different hexon structures in HAdV-D26.
  • fig. S5. Structural superposition and sequence alignment of PBs from HAdV-D26 and HAdV-C5.
  • fig. S6. Interactions between the conserved N terminus of the fiber and the PB in HAdV-D26.
  • fig. S7. The structure and analysis of the fiber molecule obtained by LAR.
  • fig. S8. Interactions between the protein IX triskelions and the hexons.
  • fig. S9. The structural overlay of the 4-HLXBs of IX from HAdV-D26 and HAdV-C5.
  • fig. S10. Structural superposition of the protein IX molecules.
  • fig. S11. Structural conservation in protein VIII molecules from HAdV-D26 and HAdV-C5.
  • fig. S12. Molecular clamping interactions by the protein VIII.
  • fig. S13. β strand formation by the unidentified densities.
  • fig. S14. Gluing interactions of the PPHs by protein VIII.
  • fig. S15. Structures, locations, and organization of minor proteins relative to the MCPs in HAdV-D26.
  • fig. S16. Structural similarities of the IIIa proteins from HAdV-D26 and HAdV-C5.
  • fig. S17. Cryo-EM density and fit of the APD of IIIa in HAdV-D26.
  • fig. S18. Gluing interactions involving IIIa, PPHs, and PB.

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