Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. The transition from self-renewal to differentiation at S0/S1 is associated
    with a transient increase in intra–S-phase DNA synthesis rate.
  • fig. S2. p57KIP2 exerts dose-dependent inhibition of DNA synthesis within S-phase
    cells.
  • fig. S3. Increased γH2AX in p57KIP2-deficient fetal liver.
  • fig. S4. Analysis of p57KIP2-deficient CFUe undergoing self-renewal in vitro.
  • fig. S5. Increased cell death in p57KIP2−/− S0 CFUe during self-renewal in vitro.
  • fig. S6. CFUe self-renewal requires the CDK-binding and inhibition functions of
    p57KIP2.
  • fig. S7. DNA combing analysis of freshly explanted fetal livers from wild-type and p57KIP2+/−m embryos associated with the experiment in Fig. 6.
  • fig. S8. DNA combing experiments.
  • fig. S9. DNA combing: Example of fluorescence image file used for scoring data.

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Other Supplementary Material for this manuscript includes the following:

  • data file S1 (Microsoft Excel format). Spreadsheet containing the data set for the
    DNA combing experiment in Fig. 6.
  • Image files (.pdf format)

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