Science Advances

Supplementary Materials

This PDF file includes:

  • section S1. The Denisova 2 specimen
  • section S2. Authenticating the DNA sequences
  • section S3. The mtDNA sequence of Denisova 2
  • section S4. Nuclear DNA sequences from Denisova 2
  • fig. S1. The Denisova 2 specimen.
  • fig. S2. The Denisova 2 specimen.
  • fig. S3. Biplot of cervical buccolingual (BL) and mesiodistal (MD) diameters.
  • fig. S4. Characteristic of DNA fragments from the two libraries prepared from the Denisova 2 specimen, per size bin.
  • fig. S5. Frequency of nucleotide substitutions in the Denisova 2 sequences.
  • fig. S6. Reconstructing the Denisova 2 mitochondrial genome.
  • fig. S7. Sex determination of Denisova 2.
  • fig. S8. Lineage attribution of two other low-coverage Denisovan individuals.
  • fig. S9. Testing our power to detect the sharing of derived alleles between Denisovans and present-day humans.
  • fig. S10. Ancestral allele counts in Denisovan and Neandertal sequences at sites that are fixed or nearly fixed for a derived allele in present-day humans.
  • table S1. Metric comparisons of cervical and maximum mesiodistal and buccolingual diameters of Denisova 2, Neandertals, and recent and Upper Paleolithic modern humans.
  • table S2. Characteristics of the DNA libraries prepared from Denisova 2.
  • table S3. Frequencies of terminal C-to-T substitutions to the human reference genome.
  • table S4. Percentage and number of sequences matching the derived state of mitochondrial genomes from three hominin groups.
  • table S5. Number of base differences between the Denisova 2 mtDNA and other mtDNAs.
  • table S6. Estimates of DNA divergence between low-coverage archaic genomes and the high-coverage genomes of a Denisovan, a Neandertal, and 12 present-day humans.
  • table S7. Estimates of DNA divergence between subsampled genomes and the high-coverage genomes of a Denisovan, a Neandertal, and 12 present-day humans.
  • table S8. Sharing of derived alleles between Denisova 2 and present-day humans.
  • table S9. Denisova-specific nonsynonymous coding changes corroborated by sequences from Denisova 2, 4, or 8.
  • References (70–82)

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