Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Discussion
  • fig. S1. QD characterization and EPR analysis.
  • fig. S2. Growth curves for SodA and SodC deletion and SodA overexpression constructs and DCFH-DA controls.
  • fig. S3. Chloramphenicol GIC50.
  • fig. S4. Streptomycin GIC50.
  • fig. S5. Ciprofloxacin GIC50.
  • fig. S6. Clindamycin GIC50.
  • fig. S7. Ceftriaxone GIC50.
  • fig. S8. Growth curve of clinical strains subjected to treatment with different concentrations of streptomycin and CdTe-2.4.
  • fig. S9. Growth curve of clinical strains subjected to treatment with different concentrations of ciprofloxacin and CdTe-2.4.
  • fig. S10. Growth curve of clinical strains subjected to treatment with different concentrations of clindamycin and CdTe-2.4.
  • fig. S11. Growth curve of clinical strains subjected to treatment with different concentrations of chloramphenicol and CdTe-2.4.
  • fig. S12. Growth curve of clinical strains subjected to treatment with different concentrations of ceftriaxone and CdTe-2.4.
  • fig. S13. Effect of antibiotics in combination with CdTe-2.4.
  • fig. S14. S parameter heat maps for combinations of CdTe-2.4 and antibiotics.
  • fig. S15. LDH assay results for HeLa cells under CdTe-2.4 treatment and MitoTracker staining.
  • fig. S16. CFU per milliliter data for HeLa infection assay.
  • fig. S17. Clinical strain screen for pathogen of C. elegans.
  • fig. S18. Isosurfaces for respective antibiotic and clinical strain based on optical density at 8 hours normalized to no treatment.
  • fig. S19. Inhibition of clinical isolates with CdTe-2.4 with varied light intensity.
  • fig. S20. CdTe-2.4 superoxide production.
  • table S1. Details for clinical isolates used in the study.
  • table S2. Concentrations of antibiotics tested (micrograms per milliliter) for each clinical isolate bacterial strain in combination therapy.
  • table S3. Nonclinically isolated E. coli strains used in studies.
  • table S4. Sensitive/resistant breakpoints used for determining resistance of clinical strains.
  • References (37–41)

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