Science Advances

Supplementary Materials

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  • Supplementary Text
  • fig. S1. Characterization of sensor function in vitro.
  • fig. S2. Single-sensor HE4 response characterization.
  • fig. S3. Images taken during the procedure to surgically implant the sensor devices.
  • fig. S4. Baseline subtraction procedure of a spectrum obtained from the implanted sensor device in vivo (E3 = one thousand units).
  • fig. S5. Raw and fitted sensor data from all mice in the exogenous protein injection experiment.
  • fig. S6. H&E stain of tumor nodules in tissue resected from each murine model of ovarian cancer.
  • fig. S7. Sensor implant emission data from all murine orthotopic ovarian cancer models.
  • fig. S8. In vivo sensor stability.
  • table S1. Change in the nanotube emission wavelength of the DNA-SWCNT following conjugation of the anti-HE4 antibody to the DNA.
  • table S2. Concentration of HE4 in conditioned cell culture media and ascites from representative mouse ascites samples as determined by ELISA of SK-OV-3, OVCAR-8, OVCAR-3, and OVCAR-5 models in vitro and in vivo.

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