Science Advances

Supplementary Materials

This PDF file includes:

  • Assessment of folding of DNA sequences
  • Characterization of structure
  • Identification of topology
  • NMR chemical shifts tables
  • Structural statistics tables
  • Fig. S1. Expansions of 1D NMR spectra of imino proton regions for DNA sequences folding into quadruplexes in this study.
  • Fig. S2. NMR structure characterization of 2MFT.
  • Fig. S3. NMR structure characterization of aromatic and anomeric regions of 2MW6.
  • Fig. S4. NMR structure characterization of inosine substitutions for 2MW6.
  • Fig. S5. Intraresidue aromatic-imino assignments for guanines in the stem of 2MW6.
  • Fig. S6. Exchangeable proton assignments for the structure of 2M6W.
  • Fig. S7. Nonexchangeable 1H and 31P assignments for 5J6U.
  • Fig. S8. Exchangeable proton assignments for 5J6U.
  • Fig. S9. Nonexchangeable 1H assignments for 5J05.
  • Fig. S10. Exchangeable proton assignments for 5J05.
  • Fig. S11. Sequence-specific assignments for 5J4W.
  • Fig. S12. Exchangeable proton assignments for 5J4W.
  • Fig. S13. Nonexchangeable 1H assignments for 5J4P.
  • Fig. S14. Exchangeable proton assignments for 5J4P.
  • Fig. S15. Nonexchangeable 1H and 31P assignments for 2M6V.
  • Fig. S16. Exchangeable proton perturbations for the inosine substitutions on 2M6V.
  • Fig. S17. Exchangeable proton assignments for 2M6V.
  • Fig. S18. NMR experiments for characterization of the 4(−lwd+ln) topology formed by the DNA sequences S069, S067, S036, and S080.
  • Fig. S19. Solution NMR experiments for characterization of the 3(−lwd+ln) topology formed by the DNA sequences S231, S090, S089, S088, and S093.
  • Fig. S20. Solution NMR experiments for characterization of the 2(−lwd+ln) topology formed by the DNA sequences S167, S171, and S172.
  • Fig. S21. Use of riboguanosines to induce folding of the 3(−lwd+ln) topology.
  • Fig. S22. Exchangeable proton assignments for 3(−lwd+ln) topology formed by S090.
  • Table S1. Proton chemical shifts for the structure of 2MFT.
  • Table S2. Proton and phosphorous chemical shifts for structure of 2M6W.
  • Table S3. Proton and phosphorous chemical shifts for structure of 5J6U.
  • Table S4. Proton chemical shifts for the structure of 5J05.
  • Table S5. Proton chemical shifts for the structure of 5J4W.
  • Table S6. Proton chemical shifts for the structure of 5J4P.
  • Table S7. Proton and phosphorous chemical shifts for the structure of 2M6V.
  • Table S8. NMR restraints and structural statistics for the structures of 2MFT.
  • Table S9. NMR restraints and structural statistics for the structures of 2M6W.
  • Table S10. NMR restraints and structural statistics for the structures of 5J6U.
  • Table S11. NMR restraints and structural statistics for the structures of 5J05.
  • Table S12. NMR restraints and structural statistics for the structures of 5J4W.
  • Table S13. NMR restraints and structural statistics for the structures of 5J4P.
  • Table S14. NMR restraints and structural statistics for the structures of 2M6V.

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