Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. The effect of mETC inhibitors on the viability of assay cells (HepG2).
  • Fig. S2. The effect of UPP inhibitors on the viability of assay cells and the common TFAP signatures for UPP inhibitors in HEK293 and MCF-7 cells.
  • Fig. S3. The common TFAP signatures for HDAC inhibitors in HEK293 and MCF-7 cells and the effect of HDAC inhibitors on the viability of assay cells.
  • Fig. S4. The effect of MTDs on the viability of assay cells.
  • Fig. S5. The effect of microtubule DNA-damaging agents on the viability of assay cells.
  • Fig. S6. An alternative presentation of TF responses to perturbagens as a heatmap.
  • Fig. S7. The list of known mitochondria disruptors with a high (r > 0.800) TFAP similarity to the mETC TFAP that were scored negative by the MMP assay.
  • Table S1. ToxCast chemicals with a high (r ≥ 0.800) similarity to the invariant mETC TFAP.
  • References (4165)

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