Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Effect of expression system on antigenicity and glycosylation of BG505 Env trimers.
  • Fig. S2. Biochemical and biophysical characterization of diverse Env trimers.
  • Fig. S3. Structural characterization of diverse UFO-BG trimers.
  • Fig. S4. Antigenic profiles of UFO and UFO-BG trimers derived from 10 strains of five subtypes assessed against a panel of 11 bNAbs, 8 non-NAbs, and CD4-Ig.
  • Fig. S5. Evolutionary root of metastability and design of UFO-C trimers containing a database-derived ancestral gp41ECTO.
  • Fig. S6. Characterization of gp41ECTO-stabilized trimer-presenting nanoparticles.
  • Fig. S7. B cell activation and in vivo evaluation of gp41ECTO-stabilized trimers and nanoparticles.
  • Table S1. X-ray data collection and refinement statistics.

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