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Supplementary Materials

The PDF file includes:

  • Fig. S1. Effect of GO289 on circadian period, CKI activity, and CRY stability.
  • Fig. S2. Effect of GO289 on kinase activity.
  • Fig. S3. Effect of CKI inhibitor LH846 and GSK-3 inhibitor CHIR-99021 on the immunoreactivity of an anti-phospho CK2 substrate antibody.
  • Fig. S4. Effect of CK2 inhibition on the growth and circadian rhythms of cancer cells.
  • Fig. S5. Effect of GO289 derivatives on CK2 activity.
  • Fig. S6. Structural features of the CK2α-GO289 complex.
  • Fig. S7. Mouse Per2 gene knockout with CRISPR-Cas9.
  • Table S1. Effect of GO289 on the phosphorylation of PER2 residues previously reported to be phosphorylated by CK2.
  • Table S2. Data collection and refinement statistics.
  • Table S3. Statistical analysis of Figs. 3E and 5A.
  • Data file S1. Compound synthesis.

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