- CRISPR/Cas9 gene drives in genetically variable and nonrandomly mating wild populations
Mating system and genetic variation impede the spread of gene drives, which target natural populations of disease-vectoring insects.
- The timetable of evolution
An increasingly well-resolved timetable of evolution provides new challenges and opportunities for evolutionary theory.
- Divergence of species responses to climate change
Traits determine species responses to climate change, as most eastern U.S. trees shift westward following moisture change.
- How birds direct impulse to minimize the energetic cost of foraging flight
Parrotlets direct leg takeoff force to minimize energy costs of foraging flights across different distances and inclinations.
- Chiral plasmonics
We present a comprehensive overview of chirality and its optical manifestation in plasmonic nanosystems and nanostructures.
- Fast label-free multilayered histology-like imaging of human breast cancer by photoacoustic microscopy
A photoacoustic microscope system provides label-free multilayered histology-like imaging of unprocessed human breast specimens.
- Does basic energy access generate socioeconomic benefits? A field experiment with off-grid solar power in India
Basic solar microgrids can significantly improve access to electricity in an affordable manner, but they generate few socioeconomic benefits.
- Antibody-mediated neutralization of soluble MIC significantly enhances CTLA4 blockade therapy
Cooperative therapeutic effect of anti-CTLA4 and anti-sMIC antibodies.
- Perpetuating the myth of the return of native forests
Still missing the forest: Optimistic claims of forest recovery based on research that lumps tree plantations with native forests are misleading.
- Cyclical nursing patterns in wild orangutans
Immature wild orangutans cyclically vary mothers’ milk consumption over 8 or more years, weaning later than other mammals.
- Direct quantitative measurement of the C═O⋅⋅⋅H–C bond by atomic force microscopy
Atomic force microscopy can image the hydrogen atoms of single molecules via very weak hydrogen bonding.
- The exceptional sediment load of fine-grained dispersal systems: Example of the Yellow River, China
We analyze why the sediment discharges of fine-grained rivers are an order of magnitude larger than predicted by current theory.
- Fast iodide-SAD phasing for high-throughput membrane protein structure determination
A potentially universal method for the de novo solution of the crystal structures of membrane proteins is described.
- Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions
A three-dimensional culture system enables maintenance of pluripotent stem cells (PSCs) and formation of PSC-derived organoids.
About The Cover
ONLINE COVER To determine how North Africa's climate has evolved over the past millions of years, experts have studied dust flux records from marine sediments. These long-term records are based largely on fluxes calculated using age model-based mass accumulation rates (MARs). However, this method suffers from many potential biases, including limited resolution. The paleoclimate community has recently diverted from the MAR approach and has started to use constant flux proxies, such as excess 230Th from seawater that can be used to determine sediment accumulation rates. Relying on 230Th from marine sediment cores to more reliably calculate fluxes, Skonieczny et al. present the first Saharan dust record than spans many glacial cycles. They discovered that in the Sahara Desert, dust emissions over the last 240,000 years have varied in accordance with Northern Hemisphere summer monsoons rather than glacial-interglacial changes as had been previously assumed. These results question the use of existing Pleistocene dust records to examine the connections between climate and hominid evolution. CREDIT: GIDEON MENDEL/CORBIS VIA GETTY IMAGES