Table 1 Summary of the interaction kinetics of environmental chemicals with mouse P-gp.

Compounds that were inhibitors in both assays and present in humans are in boldface. Compounds that were inhibitors in both assays but not known to be detected in humans are italicized. Y, yes; N, no; HCH, hexachlorocyclohexane; DDD, dichlorodiphenyldichloroethane; DDE, dichlorodiphenyldichloroethylene; DDT, dichlorodiphenyltrichloroethane; PFOA, perfluorooctanoic acid; PFOS, perfluorooctane sulfonate; DEHP, di(2-ethylhexyl)phthalate; NI, noninteraction; DL, dioxin-like PCB congeners.

Chemical	IC₅₀ (μM)^*	I_Max (%)^†	I_Yeast^‡
Organochlorine pesticides
Aldrin	26.2 (±1.9)	0.93	Y
Dieldrin	21.8 (±4.2)	0.69	Y
Endrin	1.1 (±0.7)	0.51	Y
α-HCH	26.8 (±18.0)	0.09	N
β-HCH	NI	0.00	N
γ-HCH (lindane)	82.6 (±9.9)	0.58	N
Heptachlor	10.4 (±0.9)	0.98	N
Hexachlorobenzene	NI	0.00	N
Methoxychlor	21.7 (±2.4)	0.57	N
Mirex	3 (±0.2)	0.24	N
4,4′-DDD	72.5 (±5.7)	0.45	Y
4,4′-DDE	31.3 (±3.7)	0.63	Y
4,4′-DDT	25.6 (±4.8)	0.61	Y
Polybrominated diphenyl ethers
PBDE-3	NI	0.00	N
PBDE-47	22.6 (±6.2)	0.52	Y
PBDE-49	35.6 (±5.4)	0.52	Y
PBDE-100	23.2 (±2.9)	0.68	Y
PBDE-209	6.5 (±0.4)	0.94	N
Perfluorochemicals
PFOA	156.5 (±6.1)	1.20	N
PFOS	NI	0.00	N
Plastic-related compounds
Bisphenol A	NI	0.00	N
DEHP	NI	0.00	N
Polychlorinated biphenyls
PCB-118^DL	15.9 (±1.0)	0.89	N
PCB-134^§	12.5 (±0.8)	0.82	Y
PCB-142	6.1 (±0.7)	0.90	Y
PCB-145	4.4 (±0.4)	0.92	Y
PCB-146	12.8 (±1.9)	0.50	Y
PCB-147^§	23.6 (±3.1)	0.82	Y
PCB-152	22 (±4.2)	0.84	N
PCB-153^§	21.8 (±3.1)	0.46	N
PCB-154^§	14.3 (±1.1)	0.54	N
PCB-161	43.2 (±8.3)	0.40	N
PCB-168^§	25.8 (±3.7)	0.66	N
PCB-169^DL	9.7 (±0.5)	0.93	N
PCB-170	9.2 (±0.8)	0.73	Y
PCB-186	6.9 (±0.5)	0.91	N
PCB-187	11.6 (±0.6)	0.56	Y

*Inhibition coefficients (IC₅₀) (±SD) of verapamil-stimulated ATPase activity.

†Percent maximum inhibition (I_Max).

‡Inhibition in the yeast cytotoxicity assay (I_Yeast).

§Co-elusion with other PCB congeners.