Table 1 Subject demographics for cognitively unimpaired individuals (AIBL, n = 144; KARVIAH, n = 94).

MMSE, Mini Mental State Examination; ns, not significant.

AIBL discovery cohort (11C-PiB)KARVIAH replication cohort (18FBB)
Aβ−Aβ+P valueAβ−Aβ+P value
Number of subjects (n)100445935
Aβ PET SUVR
[means (SD)]
1.16 (0.1)1.90 (0.3)1.11 × 10−541.16 (0.1)1.70 (0.2)8.35 × 10−23
Gender; females
[n (%)]
51 (50.0)21 (50.0)ns40 (67.8)21 (60.0)ns
Age in years
[means (SD)]
70.8 (7.1)75.5 (6.9)0.00177.5 (5.5)79.6 (5.3)ns
APOE ε4 carrier [n (%)]27 (27)27 (61.4)7.70 × 10−46 (10.2)15 (42.9)0.001
MMSE [means (SD)]28.9 (1.2)28.5 (1.3)ns29.4 (1.6)29.1 (1.4)ns