Table 2 Subject demographics for the mixed diagnosis cohort (AIBL, n = 190; KARVIAH, n = 94).

n/a, not available.

AIBL discovery cohort (11C-PiB)KARVIAH replication cohort (18FBB)
Aβ−Aβ+P valueAβ−Aβ+P
Number of subjects (n)108825935
Aβ PET SUVR
[means (SD)]
1.16 (0.1)2.09 (0.4)7.44 × 10−601.16 (0.1)1.70 (0.2)8.35 × 10−23
Gender; females
[n (%)]
54 (50.0)40 (48.7)ns40 (67.8)21 (60.0)ns
Age in years
[means (SD)]
71.17 (7.2)74.04 (7.7)0.01177.5 (5.5)79.6 (5.3)ns
Clinical diagnosis [n (%)]
Cognitively unimpaired
MCI
AD
100 (92.6)
7 (6.5)
1 (0.9)
44 (53.7)
14 (17.1)
24 (29.2)
3.38 × 10−1159 (100.0)
n/a
n/a
35 (100.0)
n/a
n/a
n/a
APOE ε4 carrier [n (%)]28 (25.9)54 (65.9)5.91 × 10−56 (10.2)15 (42.9)0.001
MMSE [means (SD)]28.7 (1.4)26.1 (4.0)5.96 × 10−729.4 (1.6)29.1 (1.4)ns