Table 5 Feature list for multianalyte classifier predicting elevated Aβ burden in cognitively unimpaired cohort.

The classifier was training in the AIBL cohort (n = 144), achieving a testing AUC of 0.891 in the KARVIAH cohort (n = 94). GPCR, G protein–coupled receptor; sens, sensitivity; spec, specificity.

Feature
no.
Cognitively unimpaired classifier for Aβ burden
(Testing AUC = 0.891, sens = 0.78, spec = 0.77, NPV = 0.68, PPV = 0.85)
UniProt IDFeature
description
Tryptic amino acid peptide sequences contributing to protein scores
1P00734Prothrombin87–94, 98–116, 125–133, 178–198, 199–224, 217–224, 225–243, 248–263, 315–327, 328–344, 345–363,
354–363, 441–447, 447–452, 467–468, 518–537, 544–560, and 560–575
2Q8IZF3Adhesion GPCR
F4
100–107, 315–328, 657–689, and 673–698
3P05067Aβ A4 protein677–687 and 688–699
4Q9H2A3NGN2114–120
5n/aAPOE ε4 countn/a
6Q8IVF4DNAH10
(axonemal)
207–223, 528–540, 879–915, 1133–1148, 1524–1528, 1870–1927, 2404–2436, 2906–2941, 2923–2945, and
4100–4139
7Q13127REST353–369, 727–742, and 882–896
8P07196NfL137–144, 154–164, 318–331, and 447–462
9P51812RPS6KA380–100, 109–132, 193–216, 226–242, 274–282, 508–525, and 570–591
10P81274GPSM2267–278, 318–347, and 422–433
11B1AJZ9FHAD1861–868, 876–887, 897–905, 931–942, 1030–1052, 1059–1070, and 1104–1139
12n/aAge of
participant
n/a