Table 6 Feature list for multianalyte classifier predicting elevated Aβ burden in a mixed diagnosis cohort.

The classifier was training in the AIBL cohort (n = 169), achieving a testing AUC of 0.905 in the KARVIAH cohort (n = 94).

Feature no.Mixed diagnosis classifier for Aβ burden
(Testing AUC = 0.904, sens = 0.81, spec = 0.80, NPV = 0.72, PPV = 0.87)
UniProt IDFeature
description
Tryptic amino acid peptide sequences contributing to protein scores
1n/aAPOE ε4 count*n/a
2P05067Aβ A4 protein*677–687 and 688–699
3P07196NfL*137–144, 154–164, 318–331, and 447–462
4Q9H2A3NGN2*114-120
5Q8IVF4DNAH10
(axonemal)*
207–223, 528–540, 879–915, 1133–1148, 1524–1528, 1870–1927, 2404–2436, 2906–2941,
2923–2945, and 4100–4139
6Q13127REST*353–369, 727–742, and 882–896
7O95704APBB3155–175 and 414–430
8P81274GPSM2*267–278, 318–347, and 422–433
9P00734Prothrombin*87-94, 98–116, 125–133, 178–198, 199–224, 217–224, 225–243, 248–263, 315–327, 328–344,
345–363, 354–363, 441–447, 447–452, 467–468, 518–537, 544–560, and 560–575
10B1AJZ9FHAD1*861–868, 876–887, 897–905, 931–942, 1030–1052, 1059–1070, and 1104–1139

*Proteins also included in the classifier for predicting Aβ in the cognitively unimpaired individuals.