Table 4 GLM-adjusted protein groups significantly associated with Aβ SUVR in all subjects stratified by Aβ+/− classification after Benjamini-Hochberg multiple testing corrections.

Protein groups were also associated with Aβ SUVR with an adjustment for APOE genotype. All protein groups that are nominally associated with Aβ (P > 0.05) are shown in table S2 (A and B).

UniProt IDProtein group
description
Aβ+ groupAdjusted for APOE ε4 status
tMean differenceP valueQtMean differenceP valueQ value
P05067Aβ A4 protein−6.419−0.2795.79 × 10−103.24 × 10−07−5.019−0.2209.22 × 10−070.001
Q9H2A3NGN2−5.702−0.2832.98 × 10−088.34 × 10−06−4.624−0.2315.75 × 10−060.002
P07196NfL−5.258−0.2192.88 × 10−075.38 × 10−05−3.928−0.1641.08 × 10−040.015
O95704APBB3−5.189−0.2724.05 × 10−075.67 × 10−05−3.710−0.1942.49 × 10−040.028
Q13127REST4.2470.1432.94 × 10−053.29 × 10−033.9840.1358.64 × 10−050.015
P81274GPSM24.0160.1247.61 × 10−050.0073.5640.1114.28 × 10−040.040
Q13103SPP23.8330.1081.56 × 10−040.0133.3100.0940.0010.084
Q8IVF4DNAH10
(axonemal)
−3.548−0.0904.54 × 10−040.032−3.165−0.0810.0020.120