Contents
August 2020
Vol 6, Issue 32
Vol 6, Issue 32
Contents
Research Articles
- In search of opportunity and community: Internal migration of refugees in the United States
Administrative data reveal that refugees prioritize locations with employment opportunities and existing co-national networks.
- A single molecular descriptor to predict solution behavior of therapeutic antibodies
Colloidal interactions in dilute solution singularly enable selection of well-behaved antibodies during drug discovery.
- Widespread energy limitation to life in global subseafloor sediments
The global subseafloor biosphere subsists under extreme and widespread energy limitation.
- Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses
Intranasal Q11 nanofiber vaccination activates lung dendritic cell antigen presentation and TH17 priming in both lung and lymph nodes.
- Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells
Extracellular matrix rigidity regulates how smooth muscle cells perceive contractile agonist concentration.
- Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span
Yeast cells lower their intracellular methionine level in response to glucose restriction to regulate metabolism and life span.
- Multifunctional bioactive Nd-Ca-Si glasses for fluorescence thermometry, photothermal therapy, and burn tissue repair
A multifunctional Nd-Ca-Si biomaterial is designed for fluorescence thermometry, photothermal therapy, and burn tissue repair.
- Biomolecule-guided cation regulation for dendrite-free metal anodes
Collagen hydrolysate can stabilize Zn and Li electrodeposition in metal ion batteries.
- Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T
Single-molecule imaging reveals the oligomerization state specificity of drug on its protein receptor.
- High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates
A high-throughput 3D hPSC differentiation screening strategy reveals basic and translational insight for CNS cell therapies.
- Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19
National policies for universal BCG vaccination are associated with flattened growth of country-wise COVID-19 cases and deaths.
- Nonreciprocal surface acoustic wave propagation via magneto-rotation coupling
Coupling of surface acoustic waves with anisotropic magnets demonstrates 100% nonreciprocity.
- The narrative arc: Revealing core narrative structures through text analysis
We find a consistent, unified narrative structure that can be reliably quantified using modern text analysis methods.
- When floods hit the road: Resilience to flood-related traffic disruption in the San Francisco Bay Area and beyond
Flood-related traffic disruption is not limited to the areas of inundation but has regional, spatially extended impacts.
- Generation of charge current from magnetization oscillation via the inverse of voltage-controlled magnetic anisotropy effect
We show that magnetic energy can be converted into electrical energy via inverse of voltage-controlled magnetic anisotropy effect.
- Sub–turn-on exciton quenching due to molecular orientation and polarization in organic light-emitting devices
Spontaneous orientation polarization in OLEDs reduces efficiency but can be eliminated by heating during film deposition.
- The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation
Phf19, a Polycomb subunit, controls hematopoietic stem cells identity and differentiation.
- Positive dielectrophoresis–based Raman-activated droplet sorting for culture-free and label-free screening of enzyme function in vivo
We introduce a novel, high-speed Raman-activated cell sorter (pDEP-RADS) that screens enzymes in vivo.
- Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20
This study presents structure and function of the sodium-dependent phosphate transporter, TmPiT-Pi/Na.
- Single-atom doping of MoS2 with manganese enables ultrasensitive detection of dopamine: Experimental and computational approach
We describe a flexible biosensor, based on Mn-doped MoS2, for low-level detection of dopamine in sweat and serum solution.
- Development of a potent Zika virus vaccine using self-amplifying messenger RNA
A Zika self-amplifying mRNA vaccine delivered by a flexible bedside mixing formulation induces protective immunity in NHPs.
- Using the fast impact of anthropogenic aerosols on regional land temperature to constrain aerosol forcing
Atmospheric simulations of regional land temperature suggest a powerful approach for constraining historical aerosol forcing.
- Seismological evidence for the earliest global subduction network at 2 Ga ago
Seismic imaging of Earth’s crust shows signs that subduction became a global phenomenon about 2 billion years ago.
- Rapid and robust evolution of collateral sensitivity in Pseudomonas aeruginosa antibiotic-resistant mutants
Analysis of convergent collateral sensitivity phenotypes may guide the design of antibiotic therapies in P. aeruginosa infections.
- Target switch of centipede toxins for antagonistic switch
Centipedes use toxins against conspecific centipedes or heterospecific prey species.
- Nonadiabatic exciton-phonon coupling in Raman spectroscopy of layered materials
We develop a new computational approach to resonant Raman scattering to study nonadiabatic exciton-phonon scattering.
- Infinite-order perturbative treatment for quantum evolution with exchange
A new approach for quantum evolution in dynamic systems converged to all orders in perturbation theory.
- The evolution of white matter microstructural changes after mild traumatic brain injury: A longitudinal DTI and NODDI study
We report white matter changes after mild traumatic brain injury and their relationship with self-reported and cognitive symptoms.
- Atmospheric dynamics drive most interannual U.S. droughts over the last millennium
U.S. drought is analyzed over the past millennium, showing that ENSO has some influence but much variability remains unexplained.
- Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix
Formation of solid-phase protein aggregates in mitochondria is associated with mitochondrial lipid metabolism.
- Highly variable upper and abyssal overturning cells in the South Atlantic
We present the first-ever daily time series of the full-depth volume transports by the overturning circulation cells at 34.5°S.
- Traveling and standing waves mediate pattern formation in cellular protrusions
Excitable waves evolve into standing patterns and lead to the various dynamic and static protrusions seen in migrating cells.
- Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo
Daxx loss causes coordinate dysregulation of ERVs and protein-coding genes after physiologic stress and impairs tissue recovery.
- Herbivores at the highest risk of extinction among mammals, birds, and reptiles
Herbivores have the highest representation of at-risk species in the present day, the recent past, and the late Pleistocene.
- Nematicity with a twist: Rotational symmetry breaking in a moiré superlattice
Twisted 2D materials realize a unique electronic nematic state, quite different from its counterpart in bulk quantum materials.
- Repeating earthquakes record fault weakening and healing in areas of megathrust postseismic slip
Repeating earthquakes in regions of megathrust afterslip reveal fault weakening and healing during the earthquake cycle.
- A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate
A synthetic switch shows tunable transgene expression, regulatable genome engineering, and programmable biocomputation in mammals.
- Detection and isolation of free cancer cells from ascites and peritoneal lavages using optically induced electrokinetics (OEK)
Optoelectrokinetics chip improves efficiency and sensitivity of detecting peritoneal metastasis in gastric cancer.
- Liquid repellency enhancement through flexible microstructures
Spring-like flexible supports promote the liquid repellence of mushroom-like interfacial structures.
- Fentanyl vapor self-administration model in mice to study opioid addiction
Fentanyl vapor self-administration in mice provides a novel and noninvasive model to study opioid addiction.
About The Cover
ONLINE COVER Rising sea levels raise the risk of flooding in low-lying coastal areas such as the San Francisco Bay Area, potentially disrupting urban traffic networks. When flooded roads are closed, they can create ripple effects in surrounding communities, causing employees to miss work and triggering travel delays. To better understand how near-future flooding may impact the San Francisco Bay Area, Indraneel Kasmalkar and colleagues integrated a traffic model with flood maps representing potential combinations of storm surges, tides, seasonal cycles, interannual anomalies driven by large-scale climate variability such as the El Niño Southern Oscillation, and sea level rise. The researchers found that road network connectivity–not flood exposure itself–determines commute delays in the event of a flood, with improvements in road network connectivity bolstering traffic resilience to hazards. This finding suggests coastal communities at risk for flooding–in coordination with local governments farther inland–may prepare for the future by improving road infrastructure. [CREDIT: JUSTIN SULLIVAN/GETTY IMAGES]
