Research ArticleCELL BIOLOGY

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

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Science Advances  13 Nov 2015:
Vol. 1, no. 10, e1500723
DOI: 10.1126/sciadv.1500723

Article Information

vol. 1 no. 10

Online ISSN: 
History: 
  • Received for publication June 8, 2015
  • Accepted for publication August 31, 2015

Author Information

  1. Oleg Fedorov1,2,*,
  2. Josefina Castex3,*,
  3. Cynthia Tallant1,2,*,
  4. Dafydd R. Owen4,
  5. Sarah Martin1,2,
  6. Matteo Aldeghi1,5,
  7. Octovia Monteiro1,2,
  8. Panagis Filippakopoulos2,6,
  9. Sarah Picaud2,
  10. John D. Trzupek4,
  11. Brian S. Gerstenberger4,
  12. Chas Bountra1,2,
  13. Dominica Willmann3,
  14. Christopher Wells1,2,
  15. Martin Philpott1,2,
  16. Catherine Rogers1,2,
  17. Philip C. Biggin5,
  18. Paul E. Brennan1,2,
  19. Mark E. Bunnage4,
  20. Roland Schüle3,7,8,
  21. Thomas Günther3,,
  22. Stefan Knapp1,2,9, and
  23. Susanne Müller1,2,
  1. 1Target Discovery Institute, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ, UK.
  2. 2Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
  3. 3Urologische Klinik und Zentrale Klinische Forschung, Klinikum der Universität Freiburg, Breisacher Strasse 66, 79106 Freiburg, Germany.
  4. 4Pfizer Worldwide Medicinal Chemistry, 610 Main Street, Cambridge, MA 02139, USA.
  5. 5Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
  6. 6Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, UK.
  7. 7Deutsches Konsortium für Translationale Krebsforschung, Standort Freiburg, 79106 Freiburg, Germany.
  8. 8BIOSS Centre of Biological Signalling Studies, Albert-Ludwigs-University Freiburg, 79106 Freiburg, Germany.
  9. 9Institute for Pharmaceutical Chemistry and Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.
  1. Corresponding author. E-mail: thomas.guenther{at}uniklinik-freiburg.de (T.G.); susanne.muller-knapp{at}sgc.ox.ac.uk (S.M.); knapp{at}pharmchem.uni-frankfurt.de (S.K.)
    • * These authors contributed equally to this work.

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