The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

Cornelia S. Hahn; David W. Scott; Xin Xu; Mojtaba Abdul Roda; Gregory A. Payne; J. Michael Wells; Liliana Viera; Colleen J. Winstead; Preston Bratcher; Rolf W. Sparidans; Frank A. Redegeld; Patricia L. Jackson; Gert Folkerts; J. Edwin Blalock; Rakesh P. Patel; Amit Gaggar

doi:10.1126/sciadv.1500175

Research ArticleHEALTH AND MEDICINE

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

Cornelia S. Hahn¹,²,*,
David W. Scott³,⁴,*,
Xin Xu²,⁵,*,
Mojtaba Abdul Roda²,⁶,
Gregory A. Payne²,
J. Michael Wells²,⁵,⁷,⁸,
Liliana Viera²,⁵,
Colleen J. Winstead⁴,
Preston Bratcher²,⁵,
Rolf W. Sparidans⁶,
Frank A. Redegeld⁶,
Patricia L. Jackson²,⁵,⁷,
Gert Folkerts⁶,
J. Edwin Blalock²,⁵,⁷,⁹,
Rakesh P. Patel⁴,⁵,† and
Amit Gaggar²,⁵,⁷,⁸,⁹,†,‡

¹Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
²Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
³Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁵Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁶Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.
⁷Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁸Medical Service at Birmingham VA Medical Center, Birmingham, AL 35233, USA.
⁹Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

↵‡Corresponding author. E-mail: agaggar1{at}uab.edu

↵* These authors contributed equally to this work.
↵† These authors contributed equally to this work.

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Science Advances 24 Apr 2015:
Vol. 1, no. 3, e1500175
DOI: 10.1126/sciadv.1500175

Cornelia S. Hahn

1Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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David W. Scott

3Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Xin Xu

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Mojtaba Abdul Roda

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

6Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

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Gregory A. Payne

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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J. Michael Wells

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

7Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

8Medical Service at Birmingham VA Medical Center, Birmingham, AL 35233, USA.

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Liliana Viera

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Colleen J. Winstead

4Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Preston Bratcher

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Rolf W. Sparidans

6Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

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Frank A. Redegeld

6Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

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Patricia L. Jackson

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

7Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Gert Folkerts

6Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

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J. Edwin Blalock

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

7Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

9Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Rakesh P. Patel

4Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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Amit Gaggar

2Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

5Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

7Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

8Medical Service at Birmingham VA Medical Center, Birmingham, AL 35233, USA.

9Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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For correspondence: agaggar1@uab.edu

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The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

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