The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

Cornelia S. Hahn; David W. Scott; Xin Xu; Mojtaba Abdul Roda; Gregory A. Payne; J. Michael Wells; Liliana Viera; Colleen J. Winstead; Preston Bratcher; Rolf W. Sparidans; Frank A. Redegeld; Patricia L. Jackson; Gert Folkerts; J. Edwin Blalock; Rakesh P. Patel; Amit Gaggar

doi:10.1126/sciadv.1500175

Research ArticleHEALTH AND MEDICINE

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

Cornelia S. Hahn¹,²,*,
David W. Scott³,⁴,*,
Xin Xu²,⁵,*,
Mojtaba Abdul Roda²,⁶,
Gregory A. Payne²,
J. Michael Wells²,⁵,⁷,⁸,
Liliana Viera²,⁵,
Colleen J. Winstead⁴,
Preston Bratcher²,⁵,
Rolf W. Sparidans⁶,
Frank A. Redegeld⁶,
Patricia L. Jackson²,⁵,⁷,
Gert Folkerts⁶,
J. Edwin Blalock²,⁵,⁷,⁹,
Rakesh P. Patel⁴,⁵,† and
Amit Gaggar²,⁵,⁷,⁸,⁹,†,‡

¹Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
²Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
³Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
⁴Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁵Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁶Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.
⁷Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
⁸Medical Service at Birmingham VA Medical Center, Birmingham, AL 35233, USA.
⁹Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

↵‡Corresponding author. E-mail: agaggar1{at}uab.edu

↵* These authors contributed equally to this work.
↵† These authors contributed equally to this work.

See allHide authors and affiliations

Science Advances 24 Apr 2015:
Vol. 1, no. 3, e1500175
DOI: 10.1126/sciadv.1500175

Cornelia S. Hahn

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

David W. Scott

Department of Cell Biology and Physiology, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xin Xu

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Mojtaba Abdul Roda

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gregory A. Payne

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

J. Michael Wells

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Medical Service at Birmingham VA Medical Center, Birmingham, AL 35233, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Liliana Viera

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Colleen J. Winstead

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Preston Bratcher

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rolf W. Sparidans

Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Frank A. Redegeld

Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patricia L. Jackson

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gert Folkerts

Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3508 TB Utrecht, Netherlands.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

J. Edwin Blalock

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rakesh P. Patel

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amit Gaggar

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: agaggar1@uab.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all . Please read our guidelines before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability

Plain text

Vertical Tabs

Science Advances

Article Tools