Testosterone biases the amygdala toward social threat approach

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Science Advances  12 Jun 2015:
Vol. 1, no. 5, e1400074
DOI: 10.1126/sciadv.1400074


Testosterone enhances amygdala reactions to social threat, but it remains unclear whether this neuroendocrine mechanism is relevant for understanding its dominance-enhancing properties; namely, whether testosterone biases the human amygdala toward threat approach. This pharmacological functional magnetic-resonance imaging study shows that testosterone administration increases amygdala responses in healthy women during threat approach and decreases it during threat avoidance. These findings support and extend motivational salience models by offering a neuroendocrine mechanism of motivation-specific amygdala tuning.

  • testosterone
  • amygdala
  • social approach
  • approach-avoidance
  • motivational salience

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