Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Jiyuan Ke; Honglei Ma; Xin Gu; Adam Thelen; Joseph S. Brunzelle; Jiayang Li; H. Eric Xu; Karsten Melcher

doi:10.1126/sciadv.1500107

Research ArticleSTRUCTURAL BIOLOGY

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

Jiyuan Ke¹,²,*,
Honglei Ma¹,²,*,
Xin Gu²,
Adam Thelen²,†,
Joseph S. Brunzelle³,
Jiayang Li⁴,
H. Eric Xu¹,²,‡ and
Karsten Melcher¹,²,‡

¹Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China.
²Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.
³Department of Molecular Pharmacology and Biological Chemistry, Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.
⁴State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China.

↵‡Corresponding author. E-mail: eric.xu{at}vai.org (H.E.X.); karsten.melcher{at}vai.org (K.M.)

↵* These authors contributed equally to this work.
↵† Present address: Michigan State University, East Lansing, MI 48824, USA.

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Science Advances 24 Jul 2015:
Vol. 1, no. 6, e1500107
DOI: 10.1126/sciadv.1500107

Jiyuan Ke

1Key Laboratory of Receptor Research, VARI-SIMM Center, Center for Structure and Function of Drug Targets, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People’s Republic of China.

2Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

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Honglei Ma

2Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

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Xin Gu

2Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

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Adam Thelen

2Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

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Joseph S. Brunzelle

3Department of Molecular Pharmacology and Biological Chemistry, Life Sciences Collaborative Access Team, Synchrotron Research Center, Northwestern University, Argonne, IL 60439, USA.

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Jiayang Li

4State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, People’s Republic of China.

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H. Eric Xu

2Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

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For correspondence: eric.xu@vai.org karsten.melcher@vai.org

Karsten Melcher

2Laboratory of Structural Sciences and Laboratory of Structural Biology and Biochemistry, Van Andel Research Institute, 333 Bostwick Avenue Northeast, Grand Rapids, MI 49503, USA.

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For correspondence: eric.xu@vai.org karsten.melcher@vai.org

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