Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation

Andrew T. Sage; Justin D. Besant; Laili Mahmoudian; Mahla Poudineh; Xiaohui Bai; Ricardo Zamel; Michael Hsin; Edward H. Sargent; Marcelo Cypel; Mingyao Liu; Shaf Keshavjee; Shana O. Kelley

doi:10.1126/sciadv.1500417

Research ArticleBIOSENSOR TECHNOLOGY

Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation

View ORCID ProfileAndrew T. Sage¹,
Justin D. Besant²,
View ORCID ProfileLaili Mahmoudian¹,
Mahla Poudineh³,
Xiaohui Bai⁴,⁵,
View ORCID ProfileRicardo Zamel⁴,⁵,
View ORCID ProfileMichael Hsin⁴,⁵,
Edward H. Sargent³,
Marcelo Cypel⁴,⁵,
Mingyao Liu⁴,⁵,
Shaf Keshavjee⁴,⁵ and
Shana O. Kelley¹,²,⁶,*

¹Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
²Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
³Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada.
⁴Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
⁵Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.
⁶Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

↵*Corresponding author. E-mail: shana.kelley{at}utoronto.ca

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Science Advances 28 Aug 2015:
Vol. 1, no. 7, e1500417
DOI: 10.1126/sciadv.1500417

Andrew T. Sage

1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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ORCID record for Andrew T. Sage

Justin D. Besant

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

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Laili Mahmoudian

1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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ORCID record for Laili Mahmoudian

Mahla Poudineh

3Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada.

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Xiaohui Bai

4Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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Ricardo Zamel

4Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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ORCID record for Ricardo Zamel

Michael Hsin

4Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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ORCID record for Michael Hsin

Edward H. Sargent

3Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada.

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Marcelo Cypel

4Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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Mingyao Liu

4Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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Shaf Keshavjee

4Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

5Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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Shana O. Kelley

1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

2Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

6Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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For correspondence: shana.kelley@utoronto.ca

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Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation

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