Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation

Andrew T. Sage; Justin D. Besant; Laili Mahmoudian; Mahla Poudineh; Xiaohui Bai; Ricardo Zamel; Michael Hsin; Edward H. Sargent; Marcelo Cypel; Mingyao Liu; Shaf Keshavjee; Shana O. Kelley

doi:10.1126/sciadv.1500417

Research ArticleBIOSENSOR TECHNOLOGY

Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation

Andrew T. Sage¹,
Justin D. Besant²,
Laili Mahmoudian¹,
Mahla Poudineh³,
Xiaohui Bai⁴,⁵,
Ricardo Zamel⁴,⁵,
Michael Hsin⁴,⁵,
Edward H. Sargent³,
Marcelo Cypel⁴,⁵,
Mingyao Liu⁴,⁵,
Shaf Keshavjee⁴,⁵ and
Shana O. Kelley¹,²,⁶,*

¹Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.
²Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.
³Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada.
⁴Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
⁵Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.
⁶Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

↵*Corresponding author. E-mail: shana.kelley{at}utoronto.ca

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Science Advances 28 Aug 2015:
Vol. 1, no. 7, e1500417
DOI: 10.1126/sciadv.1500417

Andrew T. Sage

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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Justin D. Besant

Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

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Laili Mahmoudian

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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Mahla Poudineh

Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada.

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Xiaohui Bai

Division of Thoracic Surgery, University of Toronto, Toronto, Ontario M5G 1L7, Canada.Latner Thoracic Surgery Research Laboratories, Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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Ricardo Zamel

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Michael Hsin

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Edward H. Sargent

Department of Electrical and Computer Engineering, University of Toronto, Toronto, Ontario M5S 3G4, Canada.

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Marcelo Cypel

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Mingyao Liu

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Shaf Keshavjee

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Shana O. Kelley

Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario M5S 3M2, Canada.Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3M2, Canada.

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For correspondence: shana.kelley@utoronto.ca

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Fractal circuit sensors enable rapid quantification of biomarkers for donor lung assessment for transplantation

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